利用酯键化学进行蛋白质连接。
Harnessing ester bond chemistry for protein ligation.
作者信息
Young P G, Yosaatmadja Y, Harris P W R, Leung I K H, Baker E N, Squire C J
机构信息
School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
出版信息
Chem Commun (Camb). 2017 Jan 26;53(9):1502-1505. doi: 10.1039/c6cc09899a.
The hydrolysis potential of ester bonds in covalently cross-linking proteins is captured in our novel protein ligation technology. This new type of "molecular superglue" based on the spontaneously-formed Thr-Gln ester bonds found in cell-surface adhesins, affords a unique mechanism to both rationally assemble and disassemble complex protein nanomaterials.
我们的新型蛋白质连接技术捕捉到了共价交联蛋白质中酯键的水解潜力。这种基于在细胞表面粘附素中发现的自发形成的苏氨酸 - 谷氨酰胺酯键的新型“分子超级胶水”，为合理组装和拆解复杂蛋白质纳米材料提供了一种独特的机制。
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