Scheithauer W, Mairinger D
Department of Gastroenterology and Hepatology II, Vienna University School of Medicine, Austria.
J Cancer Res Clin Oncol. 1989;115(5):474-5. doi: 10.1007/BF00393341.
Mouse monoclonal antibody b-12 identifies a high-molecular-mass glycoprotein antigen strongly expressed by breast carcinoma cells. Since immunohistochemical studies have also demonstrated some reactivity with other epithelial neoplasms, and since "mucine-like carcinoma-associated antigen" (MCA) has gained considerable interest as a tumor marker in breast cancer, we have investigated 34 patients with histologically proven advanced gastrointestinal malignancies for the presence of elevated MCA serum levels. Our data suggest that screening for and/or monitoring of MCA in these tumors is unlikely to have any practical clinical relevance. The possible role of MCA as a marker in tissue specimens for abortive adenomatous differentiation in gastrointestinal (and other) neoplasms, however, remains to be determined.
小鼠单克隆抗体b - 12可识别一种由乳腺癌细胞强烈表达的高分子量糖蛋白抗原。由于免疫组织化学研究也显示该抗体与其他上皮性肿瘤存在一定反应性，并且“黏液样癌相关抗原”（MCA）作为乳腺癌的肿瘤标志物已引起广泛关注，我们对34例经组织学证实的晚期胃肠道恶性肿瘤患者的血清MCA水平升高情况进行了调查。我们的数据表明，在这些肿瘤中筛查和/或监测MCA不太可能具有任何实际临床意义。然而，MCA作为胃肠道（及其他）肿瘤中腺瘤样分化失败的组织标本标志物的潜在作用仍有待确定。
