Hu Jianxia, Li Chengqian, Liu Chongkai, Zhao Shihua, Wang Yangang, Fu Zhengju
The Laboratory of Thyroid Disease, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Endocrinology Department, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Cancer Biomark. 2017;18(1):87-94. doi: 10.3233/CBM-161723.
The sensitivity and specificity of biomarkers which have been used in clinical practice for diagnosis of papillary thyroid carcinoma (PTC) are low, it is essential to develop novel diagnostic and prognostic biomarkers for PTC.
To explore the expressions of miR-940, miR-15a, miR-16 and IL-23 in PTC tissues and plasma and their associations with the clinical characteristics of PTC.
We investigated the expressions of miR-940, miR-15a, miR-16 and IL-23 in plasma and thyroid tissues of PTC, nodular goiter and healthy people with qRT-PCR, and further analyzed the associations between their levels and the clinical characteristics of PTC.
Level of IL-23 expression was higher while levels of miR-940, miR-15a and miR-16 expression in the PTC tissues were lower compared with the nodular goiter tissues and perineoplastic thyroid tissues. And the levels of miR-940, miR-15a, miR-16 and IL-23 expression in the PTC tissues were associated with some clinical characteristics of PTC, including bilateral tumor, multicentricity, extrallyroidal invasion, cervical lymph node metastasis, distant metastasis and clinical advanced stages (III/IV).
Expressions of miR-940, miR-15a, miR-16 and IL-23 in PTC tissues might be useful biomarkers and promising targets in the diagnosis of papillary thyroid carcinoma.
目前临床实践中用于诊断甲状腺乳头状癌（PTC）的生物标志物的敏感性和特异性较低，因此开发新的PTC诊断和预后生物标志物至关重要。
探讨miR-940、miR-15a、miR-16和IL-23在PTC组织和血浆中的表达及其与PTC临床特征的关系。
采用qRT-PCR检测PTC、结节性甲状腺肿和健康人群血浆及甲状腺组织中miR-940、miR-15a、miR-16和IL-23的表达，并进一步分析其水平与PTC临床特征的关系。
与结节性甲状腺肿组织和癌旁甲状腺组织相比，PTC组织中IL-23表达水平较高，而miR-940、miR-15a和miR-16表达水平较低。PTC组织中miR-940、miR-15a、miR-16和IL-23的表达水平与PTC的一些临床特征相关，包括双侧肿瘤、多中心性、甲状腺外侵犯、颈部淋巴结转移、远处转移和临床晚期（III/IV期）。
PTC组织中miR-940、miR-15a、miR-16和IL-23的表达可能是甲状腺乳头状癌诊断中有价值的生物标志物和有前景的靶点。
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