Hasegawa T, Fukushima K, Hasegawa S, Hata E, Kimura S, Ohara T
Department of Thoracic and Cardiovascular Surgery, Jichi Medical School, Tochigi, Japan.
J Cardiovasc Surg (Torino). 1989 Sep-Oct;30(5):833-7.
The effect of antiplatelet drugs on the fate of Teflon grafts placed at the superior vena cava were examined. Eighty adult mongrel dogs received dipyridamole, dipyridamole depot capsule, or cepharanthin after implantation of Teflon grafts to the superior vena cava. The incidence of graft obstruction was significantly decreased, suggesting that intimal hyperplasia was prevented by administration of antiplatelet drugs. Eighteen patients underwent various kinds of venous revascularization, including the superior caval, innominate, pulmonary, and femoral veins. The long-term outcome of prosthetic reconstruction of the superior vena cava was favorable.
研究了抗血小板药物对置于上腔静脉的聚四氟乙烯移植物转归的影响。80只成年杂种犬在上腔静脉植入聚四氟乙烯移植物后接受双嘧达莫、双嘧达莫长效胶囊或千金藤素治疗。移植物阻塞的发生率显著降低，提示抗血小板药物的给药可预防内膜增生。18例患者接受了包括上腔静脉、无名静脉、肺静脉和股静脉在内的各种静脉血管重建手术。上腔静脉人工血管重建的长期效果良好。
