Hasegawa T, Hasegawa S, Fukushima K, Watanabe N, Yokoyama H
Surgery. 1987 Sep;102(3):498-506.
The effects of cepharanthin and dipyridamole depot capsules (RAD) on the fate of Teflon fluorocarbon resin grafts used for replacement of the canine superior vena cava were studied. After short-term observation of 11 implanted grafts, 57 adult mongrel dogs underwent superior vena caval replacement with these Teflon grafts. Cepharanthin (2 mg/kg daily) and RAD (10 mg/kg daily) were administered after surgery to 28 and 14 animals, respectively. Dogs were killed at 12 days to 6 months after graft implantation. Fifteen dogs served as controls. In the cepharanthin-treated group, three grafts exhibited luminal obstruction with severe intimal hyperplasia, but smooth, semitransparent thin neointima was recognized in 25. The endothelial cell lining of the neointima exhibited excellent spread 2 months after implantation. Although one graft was obstructed with hyperproliferative fibrosis in the RAD-treated group, a well-developed neointima with complete coverage of endothelial cells was confirmed in 14 dogs. With regard to the rate of occurrence of luminal obstruction, these data were significantly different from those of the control group, which suggests that intimal hyperplasia can be reduced by treatment with antiplatelet agents.
研究了千金藤素和双嘧达莫长效胶囊（RAD）对用于替换犬上腔静脉的聚四氟乙烯氟碳树脂移植物转归的影响。对11个植入移植物进行短期观察后，57只成年杂种犬接受了用这些聚四氟乙烯移植物进行的上腔静脉置换。术后分别对28只和14只动物给予千金藤素（每日2mg/kg）和RAD（每日10mg/kg）。在移植物植入后12天至6个月处死犬。15只犬作为对照。在千金藤素治疗组，3个移植物出现管腔阻塞伴严重内膜增生，但25个移植物可见光滑、半透明的薄新生内膜。新生内膜的内皮细胞衬里在植入后2个月表现出良好的铺展。在RAD治疗组，虽然有1个移植物因增生性纤维化而阻塞，但在14只犬中证实有发育良好的新生内膜且内皮细胞完全覆盖。关于管腔阻塞的发生率，这些数据与对照组有显著差异，这表明用抗血小板药物治疗可减少内膜增生。
