Ochoa Theresa J, Sizonenko Stéphane V
a Department of Pediatrics, Universidad Peruana Cayetano Heredia, Lima, Peru.
b Department of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Biochem Cell Biol. 2017 Feb;95(1):22-30. doi: 10.1139/bcb-2016-0066. Epub 2016 Oct 26.
Lactoferrin (Lf) is the major whey protein in milk, with multiple beneficial health effects including direct antimicrobial activities, anti-inflammatory effects, and iron homeostasis. Oral Lf supplementation in human preterm infants has been shown to reduce the incidence of sepsis and necrotizing enterocolitis. In preclinical models of antenatal stress and perinatal brain injury, bovine Lf protected the developing brain from neuronal loss, improved connectivity, increased neurotrophic factors, and decreased inflammation. It also supported brain development and cognition. Further, Lf can prevent preterm delivery by reducing proinflammatory factors and inhibiting premature cervix maturation. We review here the latest research on Lf in the field of neonatology.
乳铁蛋白（Lf）是牛奶中的主要乳清蛋白，具有多种有益的健康功效，包括直接抗菌活性、抗炎作用和铁稳态调节。已证明，对人类早产儿进行口服乳铁蛋白补充可降低败血症和坏死性小肠结肠炎的发病率。在产前应激和围产期脑损伤的临床前模型中，牛乳铁蛋白可保护发育中的大脑免受神经元损失，改善连通性，增加神经营养因子，并减轻炎症。它还支持大脑发育和认知。此外，乳铁蛋白可通过减少促炎因子和抑制宫颈过早成熟来预防早产。我们在此综述新生儿学领域中关于乳铁蛋白的最新研究。
