Kazuta Toshinari, Takeda Kotaro, Osu Rieko, Tanaka Satoshi, Oishi Ayako, Kondo Kunitsugu, Liu Meigen
From the Tokyo Bay Rehabilitation Hospital, Chiba (TK, AO, KK); Yachiyo Hospital, Chiba (TK); Fujita Memorial Nanakuri Institute, Fujita Health University, Mie (KT); ATR Computational Neuroscience Laboratories, Kyoto (RO); Laboratory of Psychology, Hamamatsu University School of Medicine, Shizuoka (ST); and Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo (ML), Japan.
Am J Phys Med Rehabil. 2017 Aug;96(8):565-571. doi: 10.1097/PHM.0000000000000686.
The aim of this study was to investigate whether anodal transcranial direct current stimulation over the left temporoparietal area improved audioverbal memory performance in stroke patients.
Twelve stroke patients with audioverbal memory impairment participated in a single-masked, crossover, and sham-controlled experiment. The anodal or sham transcranial direct current stimulation was applied during the Rey Auditory Verbal Learning Test, which evaluates the ability to recall a list of 15 heard words over five trials. The number of correctly recalled words was compared between the anodal and sham conditions and the influence of transcranial direct current stimulation on serial position effect of the 15 words was also examined.
The increase in the number of correctly recalled words from the first to the fifth trial was significantly greater in the anodal condition than in the sham condition (P < 0.01). There was a significant difference (P < 0.01) between the anodal and sham conditions in the number of correctly recalled words within the first five words (primacy region) over the second to fifth trial trials, but not in the middle (next five words) or recency (last five words) regions.
Anodal transcranial direct current stimulation over the left temporoparietal area improved audioverbal memory performance and induced the primacy effect in stroke patients.
本研究旨在探讨对左侧颞顶叶区域进行阳极经颅直流电刺激是否能改善中风患者的听觉言语记忆表现。
12名患有听觉言语记忆障碍的中风患者参与了一项单盲、交叉且有假刺激对照的实验。在雷伊听觉言语学习测试期间施加阳极或假经颅直流电刺激，该测试通过五次试验评估回忆15个听到单词列表的能力。比较阳极刺激和假刺激条件下正确回忆单词的数量，并检查经颅直流电刺激对这15个单词系列位置效应的影响。
从第一次试验到第五次试验，阳极刺激条件下正确回忆单词数量的增加显著大于假刺激条件（P < 0.01）。在第二次到第五次试验中，在前五个单词（首因区）内正确回忆单词的数量，阳极刺激和假刺激条件之间存在显著差异（P < 0.01），但在中间（接下来的五个单词）或近因（最后五个单词）区域没有差异。
对左侧颞顶叶区域进行阳极经颅直流电刺激可改善中风患者的听觉言语记忆表现并诱发首因效应。
