Zokaei Nahid, Giehl Kathrin, Sillence Annie, Neville Matt J, Karpe Fredrik, Nobre Anna C, Husain Masud
Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Oxford, UK; Department of Experimental Psychology, University of Oxford, Oxford, UK.
Department of Nuclear Medicine, University of Cologne, Cologne, Germany.
Cortex. 2017 Mar;88:98-105. doi: 10.1016/j.cortex.2016.12.016. Epub 2016 Dec 24.
Short-term memory in middle-aged individuals with different APOE alleles was examined using a recently developed task which is sensitive to medial temporal lobe (MTL) damage. Individuals (age-range: 40-51 years) with ε3/ε3, ε3/ε4 and ε4/ε4 APOE genotypes (N = 60) performed a delayed estimation task with a sensitive continuous measure of report. The paradigm allowed us to measure memory for items and their locations, as well as maintenance of identity-location feature binding in memory. There was a significant gene-dosage dependent effect of the ε4 allele on performance: memory decay or forgetting was slower in ε4 carriers, as measured by localization error and after controlling for misbinding errors. Furthermore ε4 carriers made less misbinding errors. These findings were specific to male carriers only. Thus, male ε4 carriers are at a behavioral advantage in midlife on a sensitive task of short-term memory. The results would be consistent with an antagonistic pleiotropy hypothesis and hightight the interaction of gender on the influence of APOE in cognition.
使用一项最近开发的、对内侧颞叶（MTL）损伤敏感的任务，对具有不同APOE等位基因的中年个体的短期记忆进行了检查。具有ε3/ε3、ε3/ε4和ε4/ε4 APOE基因型（N = 60）的个体（年龄范围：40 - 51岁）执行了一项延迟估计任务，并采用了一种敏感的连续报告测量方法。该范式使我们能够测量对物品及其位置的记忆，以及记忆中身份 - 位置特征绑定的维持情况。ε4等位基因对表现存在显著的基因剂量依赖性效应：通过定位误差测量并在控制错配误差后发现，ε4携带者的记忆衰退或遗忘速度较慢。此外，ε4携带者的错配误差较少。这些发现仅针对男性携带者。因此，在中年时期，男性ε4携带者在一项敏感的短期记忆任务中具有行为优势。这些结果与拮抗多效性假说一致，并突出了性别在APOE对认知影响方面的相互作用。
