苦参碱通过CCR7信号减轻脂多糖诱导的肠道炎症和氧化应激。
Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal.
作者信息
Wu Guojun, Zhou Wenhong, Zhao Junfeng, Pan Xiaohua, Sun Yongjie, Xu Hao, Shi Peng, Geng Chong, Gao Ling, Tian Xingsong
机构信息
Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China.
Department of Nursing, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China.
出版信息
Oncotarget. 2017 Feb 14;8(7):11621-11628. doi: 10.18632/oncotarget.14598.
The aim of this study was to investigate the protective effects of matrine on lipopolysaccharide (LPS)-induced inflammation and oxidative stress in vivo and in vitro. The results showed that matrine improved intestinal inflammatory status and oxidative balance and enhanced chemokine receptor 7 (CCR7) expression. In LPS-challenged mice and Caco-2 cells, matrine alleviated LPS-induced inflammation and oxidative stress via downregulating pro-inflammatory cytokines (IL-1β and IL-17) and malondialdehyde (MDA) production. CCR7-siRNA transfection blocked the protective effects of matrine on LPS-induced inflammation and oxidative stress and exacerbated LPS caused injury. In conclusion, matrine alleviates LPS-induced intestinal inflammation and oxidative stress in mice and Caco-2 cells, which may be associated with CCR7 signal.
本研究旨在探讨苦参碱在体内和体外对脂多糖（LPS）诱导的炎症和氧化应激的保护作用。结果表明，苦参碱改善了肠道炎症状态和氧化平衡，并增强了趋化因子受体7（CCR7）的表达。在LPS刺激的小鼠和Caco-2细胞中，苦参碱通过下调促炎细胞因子（IL-1β和IL-17）和丙二醛（MDA）的产生，减轻了LPS诱导的炎症和氧化应激。CCR7-siRNA转染阻断了苦参碱对LPS诱导的炎症和氧化应激的保护作用，并加剧了LPS所致的损伤。总之，苦参碱减轻了LPS诱导的小鼠和Caco-2细胞的肠道炎症和氧化应激，这可能与CCR7信号有关。
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