Rao S M, Leo G J, St Aubin-Faubert P
Section of Neuropsychology, Medical College of Wisconsin, Milwaukee 53226.
J Clin Exp Neuropsychol. 1989 Oct;11(5):699-712. doi: 10.1080/01688638908400926.
Thirty-seven patients with multiple sclerosis (MS) were compared to 26 normal controls of equivalent age, education, and verbal intelligence on measures of verbal learning and memory (Digit Span and Supraspan, Brown-Peterson Distractor Task, Selective Reminding Test, Story Recall, and Free Verbal Recall) and verbal fluency (Letter and Animal Fluency). The MS patients exhibited deficits on measures of secondary (long-term) memory and verbal fluency, but performed normally on measures of primary (short-term) memory, recognition memory, and rate of forgetting from secondary memory. These results suggest that the memory disturbance in MS results primarily from an imparied ability to access information from secondary memory, while encoding and storage capacity is intact. Degree of memory impairment was unrelated to length of illness, severity of disability, or self-reported depression.
将37例多发性硬化症（MS）患者与26名年龄、教育程度和语言智力相当的正常对照者，在语言学习和记忆测量（数字广度和超广度、布朗-彼得森分心任务、选择性提醒测试、故事回忆和自由语言回忆）以及语言流畅性（字母和动物流畅性）方面进行了比较。MS患者在次级（长期）记忆和语言流畅性测量方面表现出缺陷，但在初级（短期）记忆、识别记忆以及次级记忆遗忘率的测量方面表现正常。这些结果表明，MS中的记忆障碍主要源于从次级记忆中获取信息的能力受损，而编码和存储能力完好无损。记忆损害程度与病程长短、残疾严重程度或自我报告的抑郁无关。
