Minden S L, Moes E J, Orav J, Kaplan E, Reich P
Division of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
J Clin Exp Neuropsychol. 1990 Aug;12(4):566-86. doi: 10.1080/01688639008401002.
We compared the performance of 50 multiple sclerosis (MS) patients and 35 normal controls on a variety of memory tasks to determine the nature and severity of memory deficits in the MS patients and the proportion of patients affected. We also determined the relationship between memory and other cognitive functions, demographic factors, disease characteristics, depression, and psychoactive medication. We found significant differences between patients and controls on almost all memory tests. Patterns of learning, effects of interference, and improvement with cuing were similar for both groups. Thirty percent of patients showed severe memory impairment, 30% were moderately impaired, and 40% were mildly or not impaired. Memory dysfunction was related to impairment of other cognitive functions, lower socioeconomic status, chronic progressive type of MS, and use of antianxiety medication, but not to severity of disability, duration of MS symptoms or depression.
我们比较了50名多发性硬化症（MS）患者和35名正常对照者在各种记忆任务上的表现，以确定MS患者记忆缺陷的性质和严重程度以及受影响患者的比例。我们还确定了记忆与其他认知功能、人口统计学因素、疾病特征、抑郁和精神活性药物之间的关系。我们发现，在几乎所有记忆测试中，患者和对照者之间都存在显著差异。两组在学习模式、干扰效应和线索提示后的改善方面相似。30%的患者表现出严重记忆障碍，30%为中度障碍，40%为轻度或无障碍。记忆功能障碍与其他认知功能受损、社会经济地位较低、慢性进行性MS类型以及使用抗焦虑药物有关，但与残疾严重程度、MS症状持续时间或抑郁无关。
