Inman R D, Chiu B, Rabinovich S, Marshall W
Department of Medicine, University of Toronto, Ont., Canada.
J Neuroimmunol. 1989 Sep;24(1-2):17-22. doi: 10.1016/0165-5728(89)90093-3.
This study addresses the effect of capsaicin on the severity of inflammation in experimental arthritis in the cat. Animals were sensitized with methylated bovine serum albumin (mBSA) and sequential serum antibody levels measured by enzyme-linked immunosorbent assay (ELISA). Synovitis was induced by intra-articular injection of mBSA. Histopathology revealed marked inflammatory cell infiltration and synovial cell hypercellularity, in comparison with the saline-injected control joint which showed no synovitis. In animals given intra-articular capsaicin concurrently with mBSA, there was consistently a diminution in the severity of inflammation compared with contralateral joints receiving mBSA alone. In this experimental system capsaicin appears to moderate the severity of inflammation in feline antigen-induced arthritis.
本研究探讨了辣椒素对猫实验性关节炎炎症严重程度的影响。用甲基化牛血清白蛋白（mBSA）使动物致敏，并通过酶联免疫吸附测定（ELISA）测量血清抗体水平的变化。通过关节内注射mBSA诱导滑膜炎。组织病理学显示，与未出现滑膜炎的注射生理盐水的对照关节相比，出现了明显的炎性细胞浸润和滑膜细胞增多。在与mBSA同时进行关节内注射辣椒素的动物中，与仅接受mBSA的对侧关节相比，炎症严重程度持续降低。在这个实验系统中，辣椒素似乎可以减轻猫抗原诱导性关节炎的炎症严重程度。
