关于增强子RNA和增强子转录偶联基因组不稳定性的遗留问题。
Lingering Questions about Enhancer RNA and Enhancer Transcription-Coupled Genomic Instability.
作者信息
Rothschild Gerson, Basu Uttiya
机构信息
Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
出版信息
Trends Genet. 2017 Feb;33(2):143-154. doi: 10.1016/j.tig.2016.12.002. Epub 2017 Jan 10.
Intergenic and intragenic enhancers found inside topologically associated regulatory domains (TADs) express noncoding RNAs, known as enhancer RNAs (eRNAs). Recent studies have indicated these eRNAs play a role in gene regulatory networks by controlling promoter and enhancer interactions and topology of higher-order chromatin structure. Misregulation of enhancer and promoter associated noncoding RNAs (ncRNAs) could stabilize deleterious secondary DNA structures, noncoding RNA associated DNA/RNA hybrid formation, and promote collisions of transcription complexes with replisomes. It is revealing that many chromosomal aberrations, some associated with malignancies, are present inside enhancer and/or promoter sequences. Here, we expand on current concepts to discuss enhancer RNAs and enhancer transcription, and how enhancer transcription influences genomic organization and integrity.
在拓扑相关调控结构域（TADs）内发现的基因间和基因内增强子会表达非编码RNA，即增强子RNA（eRNAs）。最近的研究表明，这些eRNAs通过控制启动子和增强子的相互作用以及高阶染色质结构的拓扑结构，在基因调控网络中发挥作用。增强子和启动子相关非编码RNA（ncRNAs）的调控异常可能会稳定有害的二级DNA结构、形成非编码RNA相关的DNA/RNA杂交体，并促进转录复合物与复制体的碰撞。越来越多的研究表明，许多染色体畸变（其中一些与恶性肿瘤相关）存在于增强子和/或启动子序列中。在这里，我们扩展了当前的概念，以讨论增强子RNA和增强子转录，以及增强子转录如何影响基因组组织和完整性。
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