Harke Shubhangi M, Khadke Suresh P, Ghadge Abhijit A, Manglekar Ashwini S, Shah Shashank S, Diwan Arundhati G, Kuvalekar Aniket A
Diabetes Laboratory, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth Deemed University, Pune-Satara Road, Pune, Maharashtra 411043, India.
Bharati Vidyapeeth Deemed University, College of Ayurved, Pune-Satara Road, Pune, Maharashtra 411043, India.
Diabetes Metab Syndr. 2017 Nov;11 Suppl 1:S273-S276. doi: 10.1016/j.dsx.2016.12.043. Epub 2016 Dec 30.
Type 2 diabetes mellitus has assumed pandemic proportions worldwide. Aggressive management of hyperglycemia in diabetics is a primary goal of treatment. We have previously reported favorable effects of oral hypoglycemic agents on adipocytokines. Aim of the present study was to investigate the relationship of adipocytokines with anthropometric measures and biochemical parameters in type 2 diabetics.
Clinically diagnosed type 2 diabetics and age, gender matched healthy volunteers were recruited for study. Anthropometric measurements like height, weight, waist-circumference, hip-circumference were recorded and BMI, waist-hip ratio were calculated. Fasting blood samples were collected from participants and sera were analyzed for glucose, glycated haemoglobin, total cholesterol, SGOT, SGPT, insulin, adiponectin and leptin. Correlation of adipocytokines with anthropometric and biochemical parameters was assessed in healthy and diabetic individuals.
BMI and WHR in diabetics were significantly higher than healthy population. BMI did not show significant association with adipocytokines. Diabetic males with WHR≥0.9 showed negative association with adiponectin and positive association with leptin. WC did not show significant association with adipocytokines in males. Irrespective of WC, healthy females exhibited positive association with leptin. Diabetic females with WC≥88cm showed leptin to be positively associated with WC. Such association of adipocytokines with WHR was not detected in females.
Body fat distribution can be considered as a parameter in assessing adipokine imbalance. Central adiposity is a better measure of adipokine imbalance than BMI. Abdominal obesity in diabetics correlates with altered levels of adipocytokines indicating its importance in diabetic individuals.
2型糖尿病在全球范围内已呈大流行态势。积极控制糖尿病患者的高血糖是治疗的主要目标。我们之前曾报道口服降糖药对脂肪细胞因子有有益作用。本研究的目的是调查2型糖尿病患者中脂肪细胞因子与人体测量指标和生化参数之间的关系。
招募临床诊断的2型糖尿病患者以及年龄、性别匹配的健康志愿者进行研究。记录身高、体重、腰围、臀围等人体测量指标，并计算体重指数（BMI）、腰臀比。采集参与者的空腹血样，分析血清中的葡萄糖、糖化血红蛋白、总胆固醇、谷草转氨酶（SGOT）、谷丙转氨酶（SGPT）、胰岛素、脂联素和瘦素。评估健康个体和糖尿病患者中脂肪细胞因子与人体测量指标和生化参数的相关性。
糖尿病患者的BMI和腰臀比显著高于健康人群。BMI与脂肪细胞因子无显著关联。腰臀比≥0.9的糖尿病男性与脂联素呈负相关，与瘦素呈正相关。男性腰围与脂肪细胞因子无显著关联。无论腰围如何，健康女性的瘦素呈正相关。腰围≥88cm的糖尿病女性，瘦素与腰围呈正相关。女性中未检测到脂肪细胞因子与腰臀比的这种关联。
体脂分布可被视为评估脂肪因子失衡的一个参数。中心性肥胖比BMI更能衡量脂肪因子失衡。糖尿病患者的腹部肥胖与脂肪细胞因子水平改变相关，表明其在糖尿病个体中的重要性。
