代谢谱对1型糖尿病儿童和青少年瘦素、脂联素及高敏C反应蛋白的影响
The Effect of Metabolic Profile on Leptin, Adiponectin, and hs-CRP in Children and Adolescents with Type 1 Diabetes.
作者信息
Kaza Maria, Tsentidis Charalampos, Vlachopapadopoulou Elpis, Sakou Irine-Ikbale, Karanasios Spyridon, Mastorakos George, Karavanaki Kyriaki
机构信息
Diabetes and Metabolism Unit, 2nd Department of Pediatrics, National and Kapodistrian University of Athens, "P&A Kyriakou" Children's Hospital, 115 27 Athens, Greece.
Department of Endocrinology, Metabolism & Diabetes Mellitus, General Hospital of Nikaia-Piraeus "Agios Panteleimon", 184 54 Piraeus, Greece.
出版信息
Children (Basel). 2022 Aug 3;9(8):1162. doi: 10.3390/children9081162.
Adipokines are a superfamily of cell signaling proteins produced by the adipose tissue. This study’s purpose was to reveal the association of adipokines (leptin, adiponectin), hs-CRP, and IL-6 with well-known cardiovascular risk factors (lipid profile, diabetes control, obesity, physical activity) in children and adolescents with T1D. This cross-sectional study included 80 participants (36 boys) with T1D, aged (mean ± SD) 14.8 ± 3.4 years. Body Mass Index (BMI), metabolic profile, and level of physical activity were assessed (using pedometers) for evaluation of their effect on serum leptin, adiponectin, IL-6, and hs-CRP. Leptin levels were associated with BMI (beta = 0.184, p < 0.001), waist to hip ratio (beta = −2.017, p = 0.022), Low Density Lipoprotein-C (LDL-C) (beta = 0.021, p = 0.005), and fat mass (beta = 14.07, p < 0.001). Adiponectin was correlated with waist to height ratio (beta = 0.048, p = 0.006), ΒΜΙ (beta = −0.056, p = 0.005), and muscle mass (beta = −0.013, p = 0.020). Interestingly, hs-CRP was associated with weight (beta = 0.035, p < 0.001), ΒΜI (beta = 0.186, p < 0.001), fat mass (beta = 5.2859, p = 0.004), and muscle mass (beta = 0.027, p = 0.008). Multiple regression analysis of muscle mass unveiled associations with log hs-CRP (beta = −1.237, p = 0.014) and inverse IL−6 (beta = 18.57, p = 0.01). Finally, multiple regression models of fat mass unveiled associations with physical activity (7-day-total-step-count) (beta = −3.90 × 10−7, p = 0.027), Inverse IL-6 (beta = −0.1572, p = 0.009), and squared leptin (beta = 0.0077, p = 0.03). This study reports a positive association of leptin with LDL-C, BMI, fat mass, and hip circumference and a negative association of adiponectin with BMI and muscle mass. Finally, hs-CRP was associated with HbA1c, fat mass, and BMI. We propose that leptin, adiponectin, and hs-CRP could be used as prognostic indicators of cardiovascular risk in children with T1D.
脂肪因子是由脂肪组织产生的细胞信号蛋白超家族。本研究的目的是揭示脂肪因子（瘦素、脂联素）、高敏C反应蛋白（hs-CRP）和白细胞介素-6（IL-6）与1型糖尿病（T1D）儿童及青少年中众所周知的心血管危险因素（血脂谱、糖尿病控制情况、肥胖、身体活动）之间的关联。这项横断面研究纳入了80名T1D参与者（36名男孩），年龄（均值±标准差）为14.8±3.4岁。评估了体重指数（BMI）、代谢谱和身体活动水平（使用计步器），以评估它们对血清瘦素、脂联素、IL-6和hs-CRP的影响。瘦素水平与BMI（β = 0.184，p < 0.001）、腰臀比（β = -2.017，p = 0.022）、低密度脂蛋白胆固醇（LDL-C）（β = 0.021，p = 0.005）和脂肪量（β = 14.07，p < 0.001）相关。脂联素与腰高比（β = 0.048，p = 0.006）、BMI（β = -0.056，p = 0.005）和肌肉量（β = -0.013，p = 0.020）相关。有趣的是，hs-CRP与体重（β = 0.035，p < 0.001）、BMI（β = 0.186，p < 0.001）、脂肪量（β = 5.2859，p = 0.004）和肌肉量（β = 0.027，p = 0.008）相关。肌肉量的多元回归分析揭示了与log hs-CRP（β = -1.237，p = 0.014）和反向IL-6（β = 18.57，p = 0.01）的关联。最后，脂肪量的多元回归模型揭示了与身体活动（7天总步数）（β = -3.90×10⁻⁷，p = 0.027）、反向IL-6（β = -0.1572，p = 0.009）和瘦素平方（β = 0.0077，p = 0.03）的关联。本研究报告了瘦素与LDL-C、BMI、脂肪量和臀围呈正相关，脂联素与BMI和肌肉量呈负相关。最后，hs-CRP与糖化血红蛋白（HbA1c）、脂肪量和BMI相关。我们提出，瘦素、脂联素和hs-CRP可作为T1D儿童心血管风险的预后指标。
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