Aleid Maha, Muneer Asif, Renshaw Sara, George Jason, Jenkinson Andrew D, Adamo Marco, Elkalaawy Mohamed, Batterham Rachel L, Ralph David J, Hashemi Majid, Cellek Selim
Cranfield University, Cranfield, Bedfordshire, UK.
University College London Hospital, London, UK; National Institute of Health Research, University College London Hospitals Biomedical Research Centre, London, UK.
J Sex Med. 2017 Feb;14(2):205-214. doi: 10.1016/j.jsxm.2016.12.004. Epub 2017 Jan 10.
Obesity is an independent risk factor for erectile dysfunction (ED) and lower urinary tract symptoms (LUTS). Bariatric surgery has been shown to improve erectile function and urinary symptoms in medium- to long-term studies (3- to 12-month postoperative follow-up).
To investigate the early effect (1 month postoperatively) of bariatric surgery on ED and LUTS, which has not previously been investigated.
Morbidly obese men (body mass index > 35 kg/m) undergoing bariatric surgery were asked to complete the International Index of Erectile Function (IIEF) and International Prostate Symptom Score (IPSS) questionnaires before surgery and 1, 3, and 6 months after surgery.
The influence of bariatric surgery on urogenital function, body mass index, fasting blood glucose, and glycated hemoglobin were analyzed using parametric and non-parametric tests for paired samples.
Of 30 patients who completed the study, 18 reported ED (IIEF score < 25) and 14 reported moderate or severe LUTS (IPSS ≥ 8) before the operation. Twelve patients had ED and moderate or severe LUTS. IIEF score, IPSS, body mass index, percentage of weight loss, fasting blood glucose, and glycated hemoglobin showed significant and rapid improvement after bariatric surgery starting at the 1-month postoperative time point and improvement continued throughout the study in all patients with ED or moderate to severe LUTS.
This is the first study showing improvement in erectile and urinary function within 1 month after bariatric surgery, an effect that was parallel to glycemic improvement and weight loss.
肥胖是勃起功能障碍（ED）和下尿路症状（LUTS）的独立危险因素。在中长期研究（术后3至12个月随访）中，减肥手术已被证明可改善勃起功能和泌尿症状。
研究减肥手术对ED和LUTS的早期影响（术后1个月），此前尚未对此进行过研究。
接受减肥手术的病态肥胖男性（体重指数>35kg/m²）被要求在手术前以及术后1、3和6个月完成国际勃起功能指数（IIEF）和国际前列腺症状评分（IPSS）问卷。
使用配对样本的参数检验和非参数检验分析减肥手术对泌尿生殖功能、体重指数、空腹血糖和糖化血红蛋白的影响。
在完成研究的30例患者中，18例在手术前报告有ED（IIEF评分<25），14例报告有中度或重度LUTS（IPSS≥8）。12例患者同时患有ED和中度或重度LUTS。IIEF评分、IPSS、体重指数、体重减轻百分比、空腹血糖和糖化血红蛋白在减肥手术后从术后1个月时间点开始显示出显著且快速的改善，并且在所有患有ED或中度至重度LUTS的患者中，这种改善在整个研究过程中持续存在。
这是第一项显示减肥手术后1个月内勃起和泌尿功能得到改善的研究，这种效果与血糖改善和体重减轻并行。
