Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK.
Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK.
Mol Cell Endocrinol. 2018 Feb 15;462(Pt B):82-92. doi: 10.1016/j.mce.2017.01.012. Epub 2017 Jan 11.
Obesity and cachexia represent divergent states of nutritional and metabolic imbalance but both are intimately linked to cancer. There is an extensive overlap in their signalling pathways and molecular components involved such as fatty acids (FAs), which likely play a crucial role in cancer. Forkhead box (FOX) proteins are responsible of a wide range of transcriptional programmes during normal development, and the FOXO3-FOXM1 axis is associated with cancer initiation, progression and drug resistance. Free fatty acids (FFAs), FA synthesis and β-oxidation are associated with cancer development and progression. Meanwhile, insulin and some adipokines, that are up-regulated by FAs, are also involved in cancer development and poor prognosis. In this review, we discuss the role of FA metabolism in cancer and how FA metabolism integrates with the FOXO3-FOXM1 axis. These new insights may provide leads to better cancer diagnostics as well as strategies for tackling cancer development, progression and drug resistance.
肥胖症和恶病质代表了营养和代谢失衡的两种不同状态，但它们都与癌症密切相关。它们的信号通路和分子成分有广泛的重叠，如脂肪酸（FAs），这些成分可能在癌症中发挥着至关重要的作用。叉头框（FOX）蛋白在正常发育过程中负责广泛的转录程序，而 FOXO3-FOXM1 轴与癌症的发生、进展和耐药性有关。游离脂肪酸（FFAs）、脂肪酸合成和β氧化与癌症的发生和发展有关。与此同时，胰岛素和一些脂肪因子（FA 上调的物质）也参与了癌症的发生和预后不良。在这篇综述中，我们讨论了 FA 代谢在癌症中的作用，以及 FA 代谢如何与 FOXO3-FOXM1 轴整合。这些新的见解可能为更好的癌症诊断以及解决癌症发展、进展和耐药性的策略提供线索。
