Van Eden C G, Mrzljak L, Voorn P, Uylings H B
Netherlands Institute for Brain Research, Amsterdam.
J Comp Neurol. 1989 Nov 8;289(2):213-27. doi: 10.1002/cne.902890204.
The present study shows that in the prenatal rat neocortex the GABA immunoreactive neurons are not limited to the marginal, subplate, and intermediate zones, but are also found in all fetal zones of the cerebral anlage. The first GABA-ergic cells are observed on embryonic day 14 in the plexiform primordium. On embryonic day 15, a second population of GABA-ergic cells is observed in the intermediate zone. Beginning on day 16 of gestation and continuing throughout gestation, GABA-ergic neurons are observed in the marginal zone, the subplate zone, the cortical plate, and the ventricular and subventricular zones. Furthermore, while the number of GABA-ergic cells in the cortical plate increases, GABA-ergic neurons in the intermediate zone and subventricular zone decrease in number after embryonic day 19.
本研究表明，在产前大鼠新皮质中，γ-氨基丁酸（GABA）免疫反应性神经元不仅局限于边缘区、板下层和中间区，在脑原基的所有胎儿区也能发现。在胚胎第14天，在丛状原基中观察到第一批GABA能细胞。在胚胎第15天，在中间区观察到第二批GABA能细胞。从妊娠第16天开始并持续整个妊娠期，在边缘区、板下层、皮质板以及脑室和室下区均观察到GABA能神经元。此外，虽然皮质板中GABA能细胞的数量增加，但在胚胎第19天后，中间区和室下区的GABA能神经元数量减少。
