Hirel Catherine, Nighoghossian Norbert, Lévêque Yohana, Hannoun Salem, Fornoni Lesly, Daligault Sébastien, Bouchet Patrick, Jung Julien, Tillmann Barbara, Caclin Anne
INSERM, U1028, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; CNRS, UMR5292, Lyon Neuroscience Research Center, Auditory Cognition and Psychoacoustics Team, Lyon F-69000, France; University Lyon 1, Villeurbanne F-69000, France; Stroke Department, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Bron F-69000, France.
University Lyon 1, Villeurbanne F-69000, France; Stroke Department, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Bron F-69000, France; CREATIS, CNRS, UMR5220, INSERM, U1044, University Lyon 1, F-69000, France.
Brain Cogn. 2017 Apr;113:10-22. doi: 10.1016/j.bandc.2017.01.003. Epub 2017 Jan 11.
Auditory cognitive deficits after stroke may concern language and/or music processing, resulting in aphasia and/or amusia. The aim of the present study was to assess the potential deficits of auditory short-term memory for verbal and musical material after stroke and their underlying cerebral correlates with a Voxel-based Lesion Symptom Mapping approach (VLSM). Patients with an ischemic stroke in the right (N=10) or left (N=10) middle cerebral artery territory and matched control participants (N=14) were tested with a detailed neuropsychological assessment including global cognitive functions, music perception and language tasks. All participants then performed verbal and musical auditory short-term memory (STM) tasks that were implemented in the same way for both materials. Participants had to indicate whether series of four words or four tones presented in pairs, were the same or different. To detect domain-general STM deficits, they also had to perform a visual STM task. Behavioral results showed that patients had lower performance for the STM tasks in comparison with control participants, regardless of the material (words, tones, visual) and the lesion side. The individual patient data showed a double dissociation between some patients exhibiting verbal deficits without musical deficits or the reverse. Exploratory VLSM analyses suggested that dorsal pathways are involved in verbal (phonetic), musical (melodic), and visual STM, while the ventral auditory pathway is involved in musical STM.
中风后的听觉认知缺陷可能涉及语言和/或音乐处理，导致失语症和/或失乐症。本研究的目的是采用基于体素的病灶症状映射方法（VLSM）评估中风后言语和音乐材料的听觉短期记忆的潜在缺陷及其潜在的脑相关性。对右侧（N = 10）或左侧（N = 10）大脑中动脉区域发生缺血性中风的患者以及匹配的对照参与者（N = 14）进行了详细的神经心理学评估，包括整体认知功能、音乐感知和语言任务。然后，所有参与者都执行了言语和音乐听觉短期记忆（STM）任务，两种材料的执行方式相同。参与者必须指出成对呈现的四个单词或四个音调序列是相同还是不同。为了检测领域通用的STM缺陷，他们还必须执行视觉STM任务。行为结果表明，与对照参与者相比，患者在STM任务中的表现较低，无论材料（单词、音调、视觉）和病灶侧如何。个体患者数据显示，一些患者表现出言语缺陷但无音乐缺陷，或反之，存在双重分离。探索性VLSM分析表明，背侧通路参与言语（语音）、音乐（旋律）和视觉STM，而腹侧听觉通路参与音乐STM。
