Jones Allison R, Bush Heather M, Frazier Susan K
University of Alabama at Birmingham School of Nursing, NB 543, 1720 2nd Ave S, Birmingham, AL 35294-1210, United States.
University of Kentucky College of Public Health, 111 Washington Ave, Lexington, KY 40536, United States.
Heart Lung. 2017 Mar-Apr;46(2):114-119. doi: 10.1016/j.hrtlng.2016.12.002. Epub 2017 Jan 12.
Blood component (packed red blood cells [PRBC], fresh frozen plasma [FFP], platelets [PLT]) ratios transfused in a 1:1:1 fashion are associated with survival after trauma; the relationship among blood component ratios and inflammatory complications after trauma is not fully understood.
To evaluate the relationship among blood component ratios (1:1 vs other for PRBC:FFP and PRBC:PLT) and inflammatory complications (primary outcome) in patients with major trauma.
Secondary analysis of a multi-institution database (N = 1538). Survival methods were used to determine the relationship among blood component ratios and inflammatory complications.
Patients were primarily male (68%), Caucasians (89%), aged 39 ± 14 years, involved in a motor vehicle collision (53%). Eighty-six percent of patients developed an inflammatory complication; 76% developed organ failure, 27% ventilator-associated pneumonia, and 24% acute respiratory distress syndrome. Injury severity, sex, and total PRBC transfusion volume, not blood component ratio, predicted inflammatory complications.
Increased understanding of factors associated with inflammation after trauma and PRBC transfusion is needed.
以1:1:1的比例输注血液成分（浓缩红细胞[PRBC]、新鲜冰冻血浆[FFP]、血小板[PLT]）与创伤后的生存率相关；创伤后血液成分比例与炎症并发症之间的关系尚未完全明确。
评估严重创伤患者血液成分比例（PRBC:FFP和PRBC:PLT为1:1与其他比例）与炎症并发症（主要结局）之间的关系。
对一个多机构数据库（N = 1538）进行二次分析。采用生存分析方法来确定血液成分比例与炎症并发症之间的关系。
患者主要为男性（68%）、白种人（89%），年龄39±14岁，因机动车碰撞受伤（53%）。86%的患者发生了炎症并发症；76%发生器官功能衰竭，27%发生呼吸机相关性肺炎，24%发生急性呼吸窘迫综合征。损伤严重程度、性别和PRBC输注总量而非血液成分比例可预测炎症并发症。
需要进一步了解创伤后与炎症及PRBC输注相关的因素。
