Pearson M J, Smart N A
School of Science and Technology, University of New England, Armidale, NSW 2351, Australia.
School of Science and Technology, University of New England, Armidale, NSW 2351, Australia.
Int J Cardiol. 2017 Mar 15;231:234-243. doi: 10.1016/j.ijcard.2016.12.145. Epub 2016 Dec 28.
Endothelial dysfunction contributes to the development and progression of cardiovascular disease and heart failure (HF) and is associated with an increased risk of mortality. Flow-mediated dilation (FMD) is widely utilised to assess endothelial function and is improved with exercise training in heart failure patients. The aim of this meta-analysis is to quantify the effect of exercise training in patients with heart failure.
A large number of studies now exist that have examined endothelial function in patients with heart failure. We sought to add to the current literature by quantifying the effect of exercise training on endothelial function.
We conducted database searches (PubMed, EMBASE, PROQUEST and Cochrane Trials Register to June 2016) for exercise based rehabilitation trials in heart failure, using search terms exercise training, endothelial function, flow-mediated dilation (FMD) and endothelial progenitor cells (EPCs).
The 16 included studies provided a total of 529 participants, 293 in an intervention and 236 in controls groups. FMD was improved with exercise training in exercise vs. control, SMD of 1.08 (95%CI 0.70 to 1.46, p<0.00001).
Overall exercise training improved endothelial function, assessed via FMD, and endothelial progenitor cells in heart failure patients.
内皮功能障碍促进心血管疾病和心力衰竭（HF）的发生发展，并与死亡风险增加相关。血流介导的血管舒张（FMD）被广泛用于评估内皮功能，且心力衰竭患者通过运动训练可使其得到改善。本荟萃分析的目的是量化运动训练对心力衰竭患者的影响。
目前已有大量研究对心力衰竭患者的内皮功能进行了检测。我们试图通过量化运动训练对内皮功能的影响来补充当前的文献资料。
我们对数据库（截至2016年6月的PubMed、EMBASE、PROQUEST和Cochrane试验注册库）进行检索，以查找心力衰竭患者基于运动的康复试验，检索词包括运动训练、内皮功能、血流介导的血管舒张（FMD）和内皮祖细胞（EPCs）。
纳入的16项研究共提供了529名参与者，其中干预组293名，对照组236名。运动组与对照组相比，运动训练使FMD得到改善，标准化均数差为1.08（95%可信区间0.70至1.46，p<0.00001）。
总体而言，运动训练改善了心力衰竭患者通过FMD评估的内皮功能以及内皮祖细胞功能。
