生发中心淋巴细胞比值与有效的 HIV 疫苗。
Germinal Center Lymphocyte Ratios and Successful HIV Vaccines.
机构信息
Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
出版信息
Trends Mol Med. 2017 Feb;23(2):95-97. doi: 10.1016/j.molmed.2016.12.009. Epub 2017 Jan 12.
Current HIV vaccines are poor inducers of neutralizing antibodies (nAbs). A recent study in Cell Reports used serial fine-needle aspirates from rhesus macaque lymph nodes following HIV-1 surface envelope glycoprotein (Env) trimer immunization, generating a substantial production of HIV-1 nAbs. A remarkable correlation was found between antibody titers and a high frequency and ratio of germinal center B and T follicular helper (T) lymphocytes.
目前的艾滋病毒疫苗在诱导中和抗体（nAbs）方面效果不佳。最近在《细胞报告》上的一项研究使用恒河猴淋巴结中 HIV-1 表面包膜糖蛋白（Env）三聚体免疫接种后的系列细针抽吸物，产生了大量的 HIV-1 nAbs。研究发现抗体滴度与生发中心 B 和滤泡辅助 T 细胞（Tfh）的高频率和高比例之间存在显著相关性。
Zotero 插件