年龄对身体活跃的成年人多巴胺D2受体水平的影响降低。
Reduced effects of age on dopamine D2 receptor levels in physically active adults.
作者信息
Dang Linh C, Castrellon Jaime J, Perkins Scott F, Le Nam T, Cowan Ronald L, Zald David H, Samanez-Larkin Gregory R
机构信息
Department of Psychology, Vanderbilt University, 219 Wilson Hall, 111 21st Avenue South, Nashville, TN 37203, USA.
Department of Psychology, Vanderbilt University, 219 Wilson Hall, 111 21st Avenue South, Nashville, TN 37203, USA.
出版信息
Neuroimage. 2017 Mar 1;148:123-129. doi: 10.1016/j.neuroimage.2017.01.018. Epub 2017 Jan 10.
Abstract
Physical activity has been shown to ameliorate dopaminergic degeneration in non-human animal models. However, the effects of regular physical activity on normal age-related changes in dopamine function in humans are unknown. Here we present cross-sectional data from forty-four healthy human subjects between 23 and 80 years old, showing that typical age-related dopamine D2 receptor loss, assessed with PET [18F]fallypride, was significantly reduced in physically active adults compared to less active adults.
摘要
在非人类动物模型中，体育活动已被证明可改善多巴胺能神经元变性。然而，规律的体育活动对人类多巴胺功能正常的年龄相关性变化的影响尚不清楚。在此，我们展示了44名年龄在23至80岁之间的健康人类受试者的横断面数据，表明与活动较少的成年人相比，在体育活动较多的成年人中，通过PET[18F]氟哌利多评估的典型年龄相关性多巴胺D2受体丧失显著减少。
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本文引用的文献
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