Bloom Michael S, Fujimoto Victor Y, Storm Robin, Zhang Li, Butts Celeste D, Sollohub Diana, Jansing Robert L
Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA; Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA.
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California at San Francisco, San Francisco, CA, USA.
Reprod Toxicol. 2017 Jan;67:165-173. doi: 10.1016/j.reprotox.2017.01.004. Epub 2017 Jan 9.
Persistent organic pollutants (POPs) are ubiquitously distributed among the U.S. population and adversely impact human reproduction. These compounds have been detected in human ovarian follicular fluid (FF), where they directly contact a developing oocyte. As a pilot investigation, we measured 43 polychlorinated biphenyl (PCB) congeners, p,p'-dichlorodiphenyltrichloroethane (DDT), and its persistent metabolite p,p'-dichlorodiphenyldichloroethylene (DDE) in residual FF collected from 32 women undergoing in vitro fertilization (IVF). We identified significant inverse associations between higher levels of PCB congeners and indicators of ovarian reserve (e.g., antral follicle count), follicular response to administered gonadotropins (e.g., peak estradiol, number of oocytes retrieved, endometrial thickness), intermediate IVF endpoints (e.g., oocyte fertilization and embryo quality), and clinical IVF outcomes (e.g., embryo implantation and live birth), after adjusting for body mass index, cigarette smoking, race, and age. Our results suggest that ongoing exposure to POPs impacts IVF and merit confirmation in a larger and more definitive future study.
持久性有机污染物（POPs）在美国人群中广泛分布，并对人类生殖产生不利影响。这些化合物已在人类卵巢卵泡液（FF）中被检测到，在那里它们直接接触发育中的卵母细胞。作为一项初步调查，我们测量了从32名接受体外受精（IVF）的女性收集的残余卵泡液中43种多氯联苯（PCB）同系物、p,p'-二氯二苯三氯乙烷（DDT）及其持久性代谢物p,p'-二氯二苯二氯乙烯（DDE）的含量。在调整了体重指数、吸烟情况、种族和年龄后，我们发现较高水平的PCB同系物与卵巢储备指标（如窦卵泡计数）、卵泡对促性腺激素给药的反应（如雌二醇峰值、回收的卵母细胞数量、子宫内膜厚度）、IVF中间终点（如卵母细胞受精和胚胎质量）以及临床IVF结局（如胚胎着床和活产）之间存在显著的负相关。我们的结果表明持续接触POPs会影响IVF，这值得在未来更大规模、更具确定性的研究中得到证实。
