Cohen-Pfeffer Jessica L, Gururangan Sridharan, Lester Thomas, Lim Daniel A, Shaywitz Adam J, Westphal Manfred, Slavc Irene
BioMarin Pharmaceutical Inc, Novato, California.
McKnight Brain Institute, University of Florida, Gainesville, Florida.
Pediatr Neurol. 2017 Feb;67:23-35. doi: 10.1016/j.pediatrneurol.2016.10.022. Epub 2016 Nov 10.
Intrathecal delivery methods have been used for many decades to treat a broad range of central nervous system disorders. A literature review demonstrated that intracerebroventricular route is an established and well-tolerated method for prolonged central nervous system drug delivery in pediatric and adult populations. Intracerebroventricular devices were present in patients from one to 7156 days. The number of punctures per device ranged from 2 to 280. Noninfectious complication rates per patient (range, 1.0% to 33.0%) were similar to infectious complication rates (0.0% to 27.0%). Clinician experience and training and the use of strict aseptic techniques have been shown to reduce the frequency of complications.
鞘内给药方法已经使用了数十年，用于治疗广泛的中枢神经系统疾病。一项文献综述表明，脑室内途径是在儿科和成人人群中进行长期中枢神经系统药物递送的一种既定且耐受性良好的方法。脑室内装置在年龄从1天至7156天的患者中使用。每个装置的穿刺次数为2至280次。每位患者的非感染性并发症发生率（范围为1.0%至33.0%）与感染性并发症发生率（0.0%至27.0%）相似。临床医生的经验和培训以及严格无菌技术的使用已被证明可降低并发症的发生率。
