Vatcheva Kristina P, Fisher-Hoch Susan P, Rahbar Mohammad H, Lee MinJae, Olvera Rene L, Mccormick Joseph B
Division of Epidemiology, University of Texas Health Science Center-Houston, School of Public Health, Brownsville Campus, Brownsville, TX.
Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Division of Clinical and Translational Sciences, Department of Internal Medicine, University of Texas Medical School at Houston, and Center for Clinical and Translational Sciences at The University of Texas Health Science Center at Houston, Room 1100.05 UT Professional Building, 6410 Fannin Street, Houston, TX.
Diabetes Res. 2015 Sep;1(4):103-112. doi: 10.17140/DROJ-1-117. Epub 2015 Sep 23.
To evaluate the relationship between total and differential White Blood Cell (WBC) counts with time to transition to type 2 diabetes in Mexican Americans using prospective data from the Cameron County Hispanic Cohort (CCHC).
Multivariable Cox proportional hazards regression models revealed that obese Mexican-American cohort participants whose total WBC or granulocyte count increased over time had 1.39 and 1.35 times higher risk respectively of transition to type 2 diabetes when compared to overweight participants. The granulocyte or total WBC count in participants with BMI≥35 were significant risk factors for transition to type 2 diabetes.
Increased total WBC and WBC differential counts, particularly lymphocytes and granulocytes, are associated with risk of transition to type 2 diabetes in obese Mexican Americans, after adjusting for other potential confounders. Screening and monitoring the WBC counts, including lymphocytes and granulocytes can help with monitoring potential transition to type 2 diabetes.
利用卡梅伦县西班牙裔队列（CCHC）的前瞻性数据，评估墨西哥裔美国人白细胞（WBC）总数及分类计数与转变为2型糖尿病的时间之间的关系。
多变量Cox比例风险回归模型显示，与超重参与者相比，白细胞总数或粒细胞计数随时间增加的肥胖墨西哥裔队列参与者转变为2型糖尿病的风险分别高1.39倍和1.35倍。体重指数（BMI）≥35的参与者的粒细胞或白细胞总数是转变为2型糖尿病的显著风险因素。
在调整其他潜在混杂因素后，白细胞总数及分类计数增加，尤其是淋巴细胞和粒细胞，与肥胖墨西哥裔美国人转变为2型糖尿病的风险相关。筛查和监测白细胞计数，包括淋巴细胞和粒细胞，有助于监测向2型糖尿病的潜在转变。
