Farhangi Mahdieh Abbasalizad, Keshavarz Seyyed-Ali, Eshraghian Mohammadreza, Ostadrahimi Alireza, Saboor-Yaraghi Ali-Akbar
Department of Community Nutrition, School of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
J Health Popul Nutr. 2013 Mar;31(1):58-64. doi: 10.3329/jhpn.v31i1.14749.
The role of white blood cell (WBC) count in pathogenesis of diabetes, cardiovascular disease, and obesity-related disorders has been reported earlier. Recent studies revealed that higher WBC contributes to atherosclerotic progression and impaired fasting glucose. However, it is unknown whether variations in WBC and haematologic profiles can occur in healthy obese individuals. The aim of this study is to further evaluate the influence of obesity on WBC count, inflammatory biomarkers, and metabolic risk factors in healthy women to establish a relationship among variables analyzed. The sample of the present study consisted of 84 healthy women with mean age of 35.56 +/- 6.83 years. They were categorized into two groups based on their body mass index (BMI): obese group with BMI > 30 kg/m2 and non-obese group with BMI < 30 kg/m2. We evaluated the relationship between WBC and platelet count (PLT) with serum interleukin 6 (IL-6), C-reactive protein (CRP), angiotensin pi (Ang pi), body fat percentage (BF %), waist-circumference (WC), and lipid profile. WBC, PLT, CRP, and IL-6 in obese subjects were significantly higher than in non-obese subjects (p < 0.05). The mean WBC count in obese subjects was 6.4 +/- 0.3 (x10(9)/L) compared to 4.4 +/- 0.3 (x10(9)/L) in non-obese subjects (p = 0.035). WBC correlated with BF% (r = 0.31, p = 0.004), CRP (r = 0.25, P = 0.03), WC (r = 0.22, p = 0.04), angiotensin 11 (r = 0.24, p = 0.03), triglyceride (r = 0.24, p = 0.03), and atherogenic index of plasma (AIP) levels (r = 0.3, p = 0.028) but not with IL-6. Platelet count was also associated with WC and waist-to-hip ratio (p < 0.05). Haemoglobin and haematocrit were in consistent relationship with LDL-cholesterol (p < 0.05). In conclusion, obesity was associated with higher WBC count and inflammatory parameters. There was also a positive relationship between WBC count and several inflammatory and metabolic risk factors in healthy women.
白细胞（WBC）计数在糖尿病、心血管疾病及肥胖相关病症发病机制中的作用，此前已有报道。近期研究表明，较高的白细胞计数会促进动脉粥样硬化进展并损害空腹血糖。然而，健康肥胖个体的白细胞及血液学指标是否会出现变化尚不清楚。本研究旨在进一步评估肥胖对健康女性白细胞计数、炎症生物标志物及代谢风险因素的影响，以确定所分析变量之间的关系。本研究样本包括84名健康女性，平均年龄为35.56±6.83岁。根据体重指数（BMI）将她们分为两组：BMI>30kg/m²的肥胖组和BMI<30kg/m²的非肥胖组。我们评估了白细胞和血小板计数（PLT）与血清白细胞介素6（IL-6）、C反应蛋白（CRP）、血管紧张素π（Ang π）、体脂百分比（BF%）、腰围（WC）及血脂谱之间的关系。肥胖受试者的白细胞、血小板计数、CRP和IL-6显著高于非肥胖受试者（p<0.05）。肥胖受试者的平均白细胞计数为6.4±0.3（×10⁹/L），而非肥胖受试者为4.4±0.3（×10⁹/L）（p = 0.035）。白细胞与BF%（r = 0.31，p = 0.004）、CRP（r = 0.25，P = 0.03）、WC（r = 0.22，p = 0.04）、血管紧张素Ⅱ（r = 0.24，p = 0.03）、甘油三酯（r = 0.24，p = 0.03）及血浆致动脉粥样硬化指数（AIP）水平（r = 0.3，p = 0.028）相关，但与IL-6无关。血小板计数也与WC及腰臀比相关（p<0.05）。血红蛋白和血细胞比容与低密度脂蛋白胆固醇呈一致关系（p<0.05）。总之，肥胖与较高的白细胞计数及炎症参数相关。健康女性的白细胞计数与多种炎症及代谢风险因素之间也存在正相关关系。
