氢质子磁共振波谱（H-MRS）测量的肝脏和肌肉异位脂肪与丹麦超重和肥胖女孩的代谢综合征有关，但与男孩无关。
H-MRS measured ectopic fat in liver and muscle is associated with the metabolic syndrome in Danish girls but not in boys with overweight and obesity.
作者信息
Nissen A, Fonvig C E, Chabanova E, Bøjsøe C, Trier C, Pedersen O, Hansen T, Thomsen H S, Holm J-C
机构信息
The Children's Obesity Clinic, Department of Pediatrics Copenhagen University Hospital Holbæk Holbæk Denmark.
The Children's Obesity Clinic, Department of Pediatrics Copenhagen University Hospital Holbæk Holbæk Denmark; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences University of @Copenhagen Copenhagen Ø Denmark.
出版信息
Obes Sci Pract. 2016 Dec;2(4):376-384. doi: 10.1002/osp4.61. Epub 2016 Sep 14.
BACKGROUND
The metabolic syndrome (MetS) is a complication to overweight and obesity, which can be observed already in childhood. Ectopic lipid accumulation in muscle and liver has been shown to associate with the development of insulin resistance and dyslipidemia. Thus, the interaction between MetS and ectopic fat may offer clinical relevance.
OBJECTIVES
To investigate the prevalence of MetS, or components hereof, and ectopic fat accumulation in liver and skeletal muscle tissue in children, as well as interactions between these.
METHODS
Two-hundred-and-sixteen children and adolescents (95 boys) with overweight/obesity were investigated, as well as 47 controls (22 boys) with normal weight. The assessments included anthropometry, fasting blood biochemistry and blood pressure measurements. Liver and muscle lipid contents were assessed by proton magnetic resonance spectroscopy.
RESULTS
We observed an odds ratio in girls with overweight/obesity of 12.2 (95% confidence interval: [3.8; 49.0]) for exhibiting MetS when hepatic steatosis was present, whereas no association was observed in boys with overweight/obesity (odds ratio 0.7 [0.2; 2.7]). The odds ratio of exhibiting MetS in the presence of muscular steatosis was 3.5 [1.4; 9.5] in girls with overweight/obesity and 1.0 [0.2; 5.6] in boys with overweight/obesity. Similar results were seen for girls with overweight/obesity exhibiting concurrent hepatic and muscular steatoses.
CONCLUSION
Hepatic and muscular steatoses were associated with MetS among girls, but not among boys with overweight/obesity.
背景
代谢综合征（MetS）是超重和肥胖的一种并发症，在儿童期即可观察到。肌肉和肝脏中的异位脂质积累已被证明与胰岛素抵抗和血脂异常的发展有关。因此，MetS与异位脂肪之间的相互作用可能具有临床意义。
目的
研究儿童中MetS或其组成成分的患病率，以及肝脏和骨骼肌组织中的异位脂肪积累情况，以及它们之间的相互作用。
方法
对216名超重/肥胖的儿童和青少年（95名男孩）以及47名体重正常的对照者（22名男孩）进行了调查。评估包括人体测量、空腹血液生化检查和血压测量。通过质子磁共振波谱评估肝脏和肌肉的脂质含量。
结果
我们观察到，存在肝脂肪变性时，超重/肥胖女孩患MetS的优势比为12.2（95%置信区间：[3.8；49.0]），而超重/肥胖男孩未观察到相关性（优势比0.7[0.2；2.7]）。存在肌肉脂肪变性时，超重/肥胖女孩患MetS的优势比为3.5[1.4；9.5]，超重/肥胖男孩为1.0[0.2；5.6]。超重/肥胖女孩同时存在肝脂肪变性和肌肉脂肪变性时也观察到类似结果。
结论
在超重/肥胖女孩中，肝脂肪变性和肌肉脂肪变性与MetS有关，但在超重/肥胖男孩中并非如此。
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