Petersen J D, Kyvik K O, Heitmann B L, Vámosi M E
Research Unit for General Practice, Department of Public Health University of Southern Denmark Odense C Denmark; Research Unit for Dietary Studies at the Parker Institute Bispebjerg and Frederiksberg Hospital Copenhagen Denmark.
Department of Clinical Research University of Southern Denmark Odense Denmark; Odense Patient Data Explorative Network Odense University Hospital Odense Denmark; The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health University of Southern Denmark Odense Denmark.
Obes Sci Pract. 2016 Dec;2(4):436-443. doi: 10.1002/osp4.79. Epub 2016 Oct 25.
The purpose of this study was to examine if parental separation during childhood is associated with obesity in adulthood.
A co-twin case-control study of 146 adult same-sexed twin pairs with discordant body mass index (BMI) (i.e. one of the twins should have a BMI of 20-25 kg/m, and the co-twin's BMI ≥ 30 kg/m) was selected from Danish Twin Registry (DTR). In total of 236 eligible twin individuals participated in the study. Childhood parental separation (defined as separation from one of the biological parents, regardless of the reason for separation) for at least one year prior to age 17 was self-reported. The statistical analysis includes logistic and linear regression models using STATA 13.0.
There were no differences in the odds of developing obesity in adulthood between the twin who stayed with a father and the co-twin who was separated from him for at least 1 year prior to age 17 [OR = 1.22, 95%CI (0.46-3.34), = 0.65]. Separation from a mother also showed no differences in the odds for developing obesity [OR = 0.90, 95%CI (0.32-2.46), = 0.82].
Because of the limited number of discordant twin pairs for childhood parental separation, we cannot provide evidence to suggest that separation from parents in childhood was associated with developing obesity in adulthood. Further studies of pooling discordant twins from several countries should be considered.
本研究旨在探讨童年时期父母离异是否与成年期肥胖有关。
从丹麦双胞胎登记处（DTR）选取了146对成年同性双胞胎进行共双胞胎病例对照研究，这些双胞胎的体重指数（BMI）不一致（即其中一个双胞胎的BMI为20-25kg/m，另一个双胞胎的BMI≥30kg/m）。共有236名符合条件的双胞胎个体参与了研究。通过自我报告获取17岁之前至少一年的童年时期父母离异情况（定义为与亲生父母一方分离，无论分离原因）。使用STATA 13.0进行统计分析，包括逻辑回归和线性回归模型。
在17岁之前与父亲生活在一起的双胞胎和与其分离至少1年的双胞胎在成年期患肥胖症的几率上没有差异[OR = 1.22，95%CI（0.46 - 3.34），P = 0.65]。与母亲分离在患肥胖症的几率上也没有差异[OR = 0.90，95%CI（0.32 - 2.46），P = 0.82]。
由于童年时期父母离异的不一致双胞胎对数量有限，我们无法提供证据表明童年时期与父母分离与成年期患肥胖症有关。应考虑对来自多个国家的不一致双胞胎进行进一步的汇总研究。
