热适应：金矿与基因。
Heat acclimation: Gold mines and genes.
作者信息
Schneider Suzanne M
机构信息
University of New Mexico, Department of Exercise Sciences , Albuquerque, NM, USA.
出版信息
Temperature (Austin). 2016 Sep 27;3(4):527-538. doi: 10.1080/23328940.2016.1240749. eCollection 2016.
Abstract
The underground gold mines of South Africa offer a unique historical setting to study heat acclimation. The early heat stress research was conducted and described by a young medical officer, Dr. Aldo Dreosti. He developed practical and specific protocols to first assess the heat tolerance of thousands of new mining recruits, and then used the screening results as the basis for assigning a heat acclimation protocol. The mines provide an interesting paradigm where the prevention of heat stroke evolved from genetic selection, where only Black natives were recruited due to a false assumption of their intrinsic tolerance to heat, to our current appreciation of the epigenetic and other molecular adaptations that occur with exposure to heat.
摘要
南非的地下金矿为研究热适应提供了独特的历史背景。早期的热应激研究是由一位年轻的医务官阿尔多·德雷奥蒂博士进行并描述的。他制定了实用且具体的方案，首先评估数千名新招募矿工的耐热性，然后将筛选结果作为制定热适应方案的依据。这些矿山提供了一个有趣的范例，从中可以看到预防中暑的方式从基因选择（由于错误地认为黑人原住民天生耐热，所以只招募他们）演变到我们如今对暴露于热环境时发生的表观遗传和其他分子适应的认识。
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