多效生长因子是胶质母细胞瘤中血管异常形成的驱动因素。
Pleiotrophin is a driver of vascular abnormalization in glioblastoma.
作者信息
Zhang Lei, Dimberg Anna
机构信息
Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory , Uppsala, Sweden.
出版信息
Mol Cell Oncol. 2016 Feb 18;3(6):e1141087. doi: 10.1080/23723556.2016.1141087. eCollection 2016.
Abstract
In a recent report by Zhang , pleiotrophin (PTN) was demonstrated to enhance glioma growth by promoting vascular abnormalization. PTN stimulates glioma vessels through anaplastic lymphoma kinase (Alk)-mediated perivascular deposition of vascular endothelial growth factor (VEGF). Targeting of Alk or VEGF signaling normalizes tumor vessels in PTN-expressing tumors.
摘要
在张最近的一份报告中，多效生长因子（PTN）被证明可通过促进血管异常来增强胶质瘤生长。PTN通过间变性淋巴瘤激酶（Alk）介导的血管内皮生长因子（VEGF）血管周围沉积来刺激胶质瘤血管。靶向Alk或VEGF信号可使表达PTN的肿瘤中的肿瘤血管正常化。
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