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本文引用的文献

1
Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.多效生长因子促进胶质瘤血管异常化，并与星形细胞瘤患者的不良生存相关。
Sci Signal. 2015 Dec 8;8(406):ra125. doi: 10.1126/scisignal.aaa1690.
2
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.弥漫性低级别胶质瘤的综合、整合基因组分析
N Engl J Med. 2015 Jun 25;372(26):2481-98. doi: 10.1056/NEJMoa1402121. Epub 2015 Jun 10.
3
Lessons from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor trials in patients with glioblastoma.胶质母细胞瘤患者抗血管内皮生长因子及抗血管内皮生长因子受体试验的经验教训。
J Clin Oncol. 2015 Apr 1;33(10):1197-213. doi: 10.1200/JCO.2014.55.9575. Epub 2015 Feb 23.
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The glioblastoma vasculature as a target for cancer therapy.作为癌症治疗靶点的胶质母细胞瘤脉管系统
Biochem Soc Trans. 2014 Dec;42(6):1647-52. doi: 10.1042/BST20140278.
5
Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.西地尼布联合放化疗后血供增加的胶质母细胞瘤患者的肿瘤氧合和生存改善。
Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19059-64. doi: 10.1073/pnas.1318022110. Epub 2013 Nov 4.
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The somatic genomic landscape of glioblastoma.胶质母细胞瘤的体细胞基因组景观。
Cell. 2013 Oct 10;155(2):462-77. doi: 10.1016/j.cell.2013.09.034.
7
Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization.人类脑胶质瘤血管的转录组分析表明 VEGF-A 和 TGFβ2 在血管异常中的关键作用。
J Pathol. 2012 Nov;228(3):378-90. doi: 10.1002/path.4072. Epub 2012 Aug 31.
8
Pleiotrophin, a multifunctional angiogenic factor: mechanisms and pathways in normal and pathological angiogenesis.多效生长因子，一种多功能血管生成因子：正常及病理性血管生成中的机制与途径
Curr Opin Hematol. 2008 May;15(3):210-4. doi: 10.1097/MOH.0b013e3282fdc69e.
9
The 2007 WHO classification of tumours of the central nervous system.2007年世界卫生组织中枢神经系统肿瘤分类
Acta Neuropathol. 2007 Aug;114(2):97-109. doi: 10.1007/s00401-007-0243-4. Epub 2007 Jul 6.
10
Ribozyme-targeting reveals the rate-limiting role of pleiotrophin in glioblastoma.靶向核酶揭示了多效生长因子在胶质母细胞瘤中的限速作用。
Int J Cancer. 2005 Dec 20;117(6):942-51. doi: 10.1002/ijc.21276.

多效生长因子是胶质母细胞瘤中血管异常形成的驱动因素。

Pleiotrophin is a driver of vascular abnormalization in glioblastoma.

作者信息

Zhang Lei, Dimberg Anna

机构信息

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory , Uppsala, Sweden.

出版信息

Mol Cell Oncol. 2016 Feb 18;3(6):e1141087. doi: 10.1080/23723556.2016.1141087. eCollection 2016.

DOI:10.1080/23723556.2016.1141087
PMID:28090572
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5160416/
Abstract

In a recent report by Zhang , pleiotrophin (PTN) was demonstrated to enhance glioma growth by promoting vascular abnormalization. PTN stimulates glioma vessels through anaplastic lymphoma kinase (Alk)-mediated perivascular deposition of vascular endothelial growth factor (VEGF). Targeting of Alk or VEGF signaling normalizes tumor vessels in PTN-expressing tumors.

摘要

在张最近的一份报告中，多效生长因子（PTN）被证明可通过促进血管异常来增强胶质瘤生长。PTN通过间变性淋巴瘤激酶（Alk）介导的血管内皮生长因子（VEGF）血管周围沉积来刺激胶质瘤血管。靶向Alk或VEGF信号可使表达PTN的肿瘤中的肿瘤血管正常化。