多效生长因子是胶质母细胞瘤中血管异常形成的驱动因素。
Pleiotrophin is a driver of vascular abnormalization in glioblastoma.
作者信息
Zhang Lei, Dimberg Anna
机构信息
Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory , Uppsala, Sweden.
出版信息
Mol Cell Oncol. 2016 Feb 18;3(6):e1141087. doi: 10.1080/23723556.2016.1141087. eCollection 2016.
Abstract
In a recent report by Zhang , pleiotrophin (PTN) was demonstrated to enhance glioma growth by promoting vascular abnormalization. PTN stimulates glioma vessels through anaplastic lymphoma kinase (Alk)-mediated perivascular deposition of vascular endothelial growth factor (VEGF). Targeting of Alk or VEGF signaling normalizes tumor vessels in PTN-expressing tumors.
摘要
在张最近的一份报告中，多效生长因子（PTN）被证明可通过促进血管异常来增强胶质瘤生长。PTN通过间变性淋巴瘤激酶（Alk）介导的血管内皮生长因子（VEGF）血管周围沉积来刺激胶质瘤血管。靶向Alk或VEGF信号可使表达PTN的肿瘤中的肿瘤血管正常化。
相似文献
1
Pleiotrophin is a driver of vascular abnormalization in glioblastoma.
Mol Cell Oncol. 2016 Feb 18;3(6):e1141087. doi: 10.1080/23723556.2016.1141087. eCollection 2016.
2
Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.
Sci Signal. 2015 Dec 8;8(406):ra125. doi: 10.1126/scisignal.aaa1690.
3
Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells.
Oncotarget. 2016 Dec 6;7(49):80382-80390. doi: 10.18632/oncotarget.12983.
4
Anaplastic lymphoma kinase: "Ligand Independent Activation" mediated by the PTN/RPTPβ/ζ signaling pathway.
Biochim Biophys Acta. 2013 Oct;1834(10):2219-23. doi: 10.1016/j.bbapap.2013.06.004. Epub 2013 Jun 15.
5
Anaplastic lymphoma kinase is expressed in different subtypes of human breast cancer.
Biochem Biophys Res Commun. 2007 Jun 29;358(2):399-403. doi: 10.1016/j.bbrc.2007.04.137. Epub 2007 Apr 30.
6
Vascular endothelial growth factor A (VEGF-A) decreases expression and secretion of pleiotrophin in a VEGF receptor-independent manner.
Vascul Pharmacol. 2016 May;80:11-9. doi: 10.1016/j.vph.2016.02.008. Epub 2016 Feb 23.
7
In contrast to agonist monoclonal antibodies, both C-terminal truncated form and full length form of Pleiotrophin failed to activate vertebrate ALK (anaplastic lymphoma kinase)?
Cell Signal. 2007 Dec;19(12):2434-43. doi: 10.1016/j.cellsig.2007.07.011. Epub 2007 Jul 25.
8
Ribozyme-targeting reveals the rate-limiting role of pleiotrophin in glioblastoma.
Int J Cancer. 2005 Dec 20;117(6):942-51. doi: 10.1002/ijc.21276.
9
Effects of pleiotrophin, a heparin-binding growth factor, on human primary and immortalized chondrocytes.
Osteoarthritis Cartilage. 2007 Feb;15(2):155-62. doi: 10.1016/j.joca.2006.07.005. Epub 2006 Sep 1.
10
Genome-wide screening identifies oncofetal lncRNA Ptn-dt promoting the proliferation of hepatocellular carcinoma cells by regulating the Ptn receptor.
Oncogene. 2019 May;38(18):3428-3445. doi: 10.1038/s41388-018-0643-z. Epub 2019 Jan 14.
引用本文的文献
1
Recent Developments in Glioblastoma-On-A-Chip for Advanced Drug Screening Applications.
Small. 2025 Jan;21(1):e2405511. doi: 10.1002/smll.202405511. Epub 2024 Nov 13.
2
Therapeutic approaches to modulate the immune microenvironment in gliomas.
NPJ Precis Oncol. 2024 Oct 23;8(1):241. doi: 10.1038/s41698-024-00717-4.
3
Single-cell analysis reveals diversity of tumor-associated macrophages and their interactions with T lymphocytes in glioblastoma.
Sci Rep. 2023 Nov 27;13(1):20874. doi: 10.1038/s41598-023-48116-2.
4
Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex.
Nat Neurosci. 2022 Aug;25(8):1034-1048. doi: 10.1038/s41593-022-01124-3. Epub 2022 Jul 25.
5
A systematic review and meta-analysis on the differentiation of glioma grade and mutational status by use of perfusion-based magnetic resonance imaging.
Insights Imaging. 2022 Jun 7;13(1):102. doi: 10.1186/s13244-022-01230-7.
6
Uncovering a Key Role of ETS1 on Vascular Abnormality in Glioblastoma.
Pathol Oncol Res. 2021 Nov 19;27:1609997. doi: 10.3389/pore.2021.1609997. eCollection 2021.
7
Genome-wide screening identifies oncofetal lncRNA Ptn-dt promoting the proliferation of hepatocellular carcinoma cells by regulating the Ptn receptor.
Oncogene. 2019 May;38(18):3428-3445. doi: 10.1038/s41388-018-0643-z. Epub 2019 Jan 14.
8
IDH mutation status is associated with distinct vascular gene expression signatures in lower-grade gliomas.
Neuro Oncol. 2018 Oct 9;20(11):1505-1516. doi: 10.1093/neuonc/noy088.
9
ALK signaling cascade confers multiple advantages to glioblastoma cells through neovascularization and cell proliferation.
PLoS One. 2017 Aug 24;12(8):e0183516. doi: 10.1371/journal.pone.0183516. eCollection 2017.
本文引用的文献
1
Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.
Sci Signal. 2015 Dec 8;8(406):ra125. doi: 10.1126/scisignal.aaa1690.
2
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
N Engl J Med. 2015 Jun 25;372(26):2481-98. doi: 10.1056/NEJMoa1402121. Epub 2015 Jun 10.
3
Lessons from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor trials in patients with glioblastoma.
J Clin Oncol. 2015 Apr 1;33(10):1197-213. doi: 10.1200/JCO.2014.55.9575. Epub 2015 Feb 23.
4
The glioblastoma vasculature as a target for cancer therapy.
Biochem Soc Trans. 2014 Dec;42(6):1647-52. doi: 10.1042/BST20140278.
5
Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.
Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19059-64. doi: 10.1073/pnas.1318022110. Epub 2013 Nov 4.
6
The somatic genomic landscape of glioblastoma.
Cell. 2013 Oct 10;155(2):462-77. doi: 10.1016/j.cell.2013.09.034.
7
Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization.
J Pathol. 2012 Nov;228(3):378-90. doi: 10.1002/path.4072. Epub 2012 Aug 31.
8
Pleiotrophin, a multifunctional angiogenic factor: mechanisms and pathways in normal and pathological angiogenesis.
Curr Opin Hematol. 2008 May;15(3):210-4. doi: 10.1097/MOH.0b013e3282fdc69e.
9
The 2007 WHO classification of tumours of the central nervous system.
Acta Neuropathol. 2007 Aug;114(2):97-109. doi: 10.1007/s00401-007-0243-4. Epub 2007 Jul 6.
10
Ribozyme-targeting reveals the rate-limiting role of pleiotrophin in glioblastoma.
Int J Cancer. 2005 Dec 20;117(6):942-51. doi: 10.1002/ijc.21276.
Zotero 插件