Menendez Javier A, Alarcón Tomás
ProCURE (Program Against Cancer Therapeutic Resistance), Metabolism and Cancer Group, Catalan Institute of Oncology, Girona, Catalonia, Spain; Molecular Oncology Group, Girona Biomedical Research Institute (IDIBGI), Salt, Catalonia, Spain.
Computational & Mathematical Biology Research Group, Center de Recerca Matemàtica, Barcelona, Catalonia, Spain; ICREA (Institució Catalana d'Estudis i Recerca Avançats), Barcelona, Spain; Departament de Matemàtiques, Universitat Autónoma de Barcelona, Barcelona, Spain; Barcelona Graduate School of Mathematics (BGSMath), Barcelona, Spain.
Mol Cell Oncol. 2016 Mar 28;3(6):e1160854. doi: 10.1080/23723556.2016.1160854. eCollection 2016.
Generation of cancer stem cell (CSC)-like cells might occur through metabolic corruption of the epigenetic codes that govern cell identity. We recently identified how archetypal oncometabolites, without altering the baseline expression of endogenous stem cell maintenance genes but endowing cells with epigenetic states refractory to differentiation, considerably enhance the global kinetic efficiency of nuclear reprogramming processes that generate CSC-like states . This study highlights that metabolo-epigenetic axes of communication can direct the development and maintenance of CSCs during the natural history of cancer diseases.
癌症干细胞（CSC）样细胞的产生可能是通过调控细胞身份的表观遗传密码的代谢破坏而发生的。我们最近发现，典型的肿瘤代谢物如何在不改变内源性干细胞维持基因的基线表达，但赋予细胞难以分化的表观遗传状态的情况下，显著提高产生CSC样状态的核重编程过程的整体动力学效率。这项研究强调，代谢-表观遗传通讯轴可以在癌症疾病的自然史中指导CSC的发育和维持。
