Koshy A, Moreau R, Cerini R, Roulot D, Bacq Y, Hadengue A, Lebrec D
Unité de Recherches de Physiopathologie Hépatique (INSERM U24), Hôpital Beaujon, Clichy, France.
J Hepatol. 1989 Sep;9(2):240-5. doi: 10.1016/0168-8278(89)90057-3.
In patients with cirrhosis, O2 uptake, i.e., O2 consumption, is abnormally decreased. We administered 50% O2 for 30 min in eight patients with alcoholic cirrhosis to determine whether the subsequent increase in arterial O2 content may correct the low O2 consumption. In addition, we studied in these patients the reflex control of cardiac output and blood pressure by arterial baroreceptors, as O2 inhalation induces a systemic vasoconstriction. Arterial O2 tension, oxyhaemoglobin saturation and arterial O2 content significantly increased as well as systemic vascular resistance and arterial pressure. In contrast, O2 consumption (which was below normal values) under basal conditions, O2 transport, O2 extraction ratio, heart rate, right atrial and pulmonary wedged pressures, cardiac output, hepatic venous pressures, hepatic and azygos blood flows were unaffected by O2 administration. In three patients receiving air, no significant change was observed. Our results show that, in patients with cirrhosis, inhalation of 50% O2 does not correct O2 consumption. We may conclude that reflex control of cardiac output and arterial pressure by arterial baroreceptors is impaired in these patients.
在肝硬化患者中，氧摄取，即氧消耗，异常降低。我们对8例酒精性肝硬化患者给予50%氧气30分钟，以确定随后动脉血氧含量的增加是否能纠正低氧消耗。此外，由于吸氧会引起全身血管收缩，我们研究了这些患者中动脉压力感受器对心输出量和血压的反射性控制。动脉血氧张力、氧合血红蛋白饱和度和动脉血氧含量显著增加，全身血管阻力和动脉压也显著增加。相比之下，基础状态下低于正常值的氧消耗、氧运输、氧摄取率、心率、右心房和肺楔压、心输出量、肝静脉压、肝和奇静脉血流量不受吸氧的影响。在3例接受空气的患者中，未观察到显著变化。我们的结果表明，在肝硬化患者中，吸入50%氧气并不能纠正氧消耗。我们可以得出结论，这些患者中动脉压力感受器对心输出量和动脉压的反射性控制受损。
