Yin H, E M, Zhang H, Wang C
Radiation Oncology Division, Harbin Medical University Affiliated Tumor Hospital, Harbin, Heilongjiang, China.
Breast Surgery Ward Three, Harbin Medical University Affiliated Tumor Hospital, Harbin, Heilongjiang, China.
Clin Transl Oncol. 2017 Jun;19(6):742-749. doi: 10.1007/s12094-016-1603-0. Epub 2017 Jan 13.
The aim of this study was to evaluate radiotherapy in terms of both feasibility and efficacy for the treatment of 206 elderly patients (≥70 years) with unresectable ESCC and to investigate the factors that predict overall survival in those patients.
Totally, 206 elderly patients with esophageal cancer (≥70 years) treated with RT for ESCC in the Harbin Medical University Affiliated Tumor Hospital were retrospectively enrolled. Radiation treatment results and side effects were evaluated. Survival data were estimated using the Kaplan-Meier method, including OS, RFS and DDFS. A multivariate Cox regression analysis was performed to determine the relevant prognostic factors.
The median OS and RFS were 20.68 and 24.19 months. Metastases before radiotherapy, having cervical or supraclavicular neoplasm, with lesion length >5 cm were the independent risk factors for OS. The total effective rate was 86.9% (179/206).
Radiation therapy in elderly patients (≥70 years) can not only obtain good treatment result, but also make patients have better tolerance and reduce the risk of complications. Radiotherapy should be as a primary treatment option for elderly patients with inoperable ESCC.
本研究旨在评估放射治疗对206例年龄≥70岁、无法切除的食管鳞癌老年患者治疗的可行性和疗效，并探究这些患者总生存的预测因素。
回顾性纳入哈尔滨医科大学附属肿瘤医院接受放射治疗的206例年龄≥70岁的老年食管癌患者。评估放射治疗结果和副作用。采用Kaplan-Meier法估计生存数据，包括总生存期（OS）、无复发生存期（RFS）和无远处转移生存期（DDFS）。进行多因素Cox回归分析以确定相关预后因素。
中位OS和RFS分别为20.68个月和24.19个月。放疗前有转移、有颈部或锁骨上肿瘤、病变长度>5 cm是OS的独立危险因素。总有效率为86.9%（179/206）。
年龄≥70岁的老年患者放射治疗不仅能取得良好的治疗效果，还能使患者有较好的耐受性并降低并发症风险。放射治疗应作为无法手术的老年食管鳞癌患者的主要治疗选择。
