Fontana A, Frei K, Bodmer S, Hofer E, Schreier M H, Palladino M A, Zinkernagel R M
Section of Clinical Immunology, University Hospital, Zürich, Switzerland.
J Immunol. 1989 Nov 15;143(10):3230-4.
The immunoregulatory effects of human recombinant transforming growth factor (rTGF) beta 1 and human recombinant glioblastoma-derived T cell suppressor factor (rG-TsF)/TGF beta 2 was investigated in mice infected with lymphocytic choriomeningitis virus (LCMV) or vaccinia virus. Starting on the day of infection, i.p. injections of 1 microgram/day or rTGF-beta 1 or rG-TsF/TGF-beta 2 suppressed the generation of virus specific CTL. The effect of TGF-beta on CTL (day 8) was less pronounced when TGF-beta treatment was delayed for 3 days after LCMV infection. rG-TsF/TGF-beta 2 also has an inhibiting effect on CTL-mediated disease in LCMV-infected mice: it prolonged the survival time of mice infected with LCMV and reduced the local swelling reaction after infection into the footpad. These results indicate that rTGF-beta 1 and rG-TsF/TGF-beta 2 influence T cell immune reactivity in vivo.
研究了人重组转化生长因子（rTGF）β1和人重组胶质母细胞瘤衍生的T细胞抑制因子（rG-TsF）/TGFβ2对感染淋巴细胞性脉络丛脑膜炎病毒（LCMV）或痘苗病毒的小鼠的免疫调节作用。从感染当天开始，腹腔注射1微克/天的rTGF-β1或rG-TsF/TGF-β2可抑制病毒特异性CTL的产生。当LCMV感染后3天延迟TGF-β治疗时，TGF-β对CTL（第8天）的作用不太明显。rG-TsF/TGF-β2对LCMV感染小鼠的CTL介导疾病也有抑制作用：它延长了感染LCMV小鼠的存活时间，并减少了感染足垫后的局部肿胀反应。这些结果表明，rTGF-β1和rG-TsF/TGF-β2在体内影响T细胞免疫反应性。
