Moreau Kerrie L, Ozemek Cemal
1Division of Geriatric Medicine, University of Colorado Anschutz Medical Campus, Aurora; 2Denver Veterans Administration Medical Center, Geriatric Research, Education and Clinical Center, Denver, CO; and 3Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL.
Exerc Sport Sci Rev. 2017 Apr;45(2):116-123. doi: 10.1249/JES.0000000000000104.
Regular exercise is promoted as a therapeutic strategy for age-associated endothelial dysfunction. Improvements in endothelial function are observed with endurance exercise in older men, but are diminished or absent in older women. This article examines the hypothesis that sex hormones modulate vascular adaptations to exercise training by influencing antioxidant defense systems, mitochondrial function, oxidative stress, and intracellular signaling.
经常锻炼被推崇为一种治疗与年龄相关的内皮功能障碍的策略。在老年男性中，耐力运动可改善内皮功能，但在老年女性中，这种改善会减弱或不存在。本文探讨了一种假说，即性激素通过影响抗氧化防御系统、线粒体功能、氧化应激和细胞内信号传导来调节血管对运动训练的适应性。
