Huang Shiqian, Zhou Yuxi, Liu Jie, Sun Shujun, Zhang Tianhao, Ma Lulin, Liu Shiya, Deng Daling, Shu Shaofang, Wang Yu, Yuan Yin, Chen Xiangdong
Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Perioper Med (Lond). 2025 Jul 22;14(1):76. doi: 10.1186/s13741-025-00565-1.
Perioperative neurocognitive dysfunction (PND) is a significant complication in elderly surgical patients, characterized by cognitive decline and often linked to neuroinflammation. This study conducted a bibliometric analysis of 744 publications on PND-related neuroinflammation from 1999 to 2023, using the Web of Science Core Collection (WoSCC) database. Tools such as VOSviewer, CiteSpace, and Microsoft Excel were employed to analyze publication trends, geographical distribution, and key research areas. Results showed a steady increase in publications, with China leading in output and the USA exerting significant influence. Key research areas included aging, cardiac surgery, microglial activation, and therapeutic targets. Recent studies focused on the NLRP3 inflammasome and microglial activation as central mechanisms. The analysis also identified emerging trends, such as the investigation of biomarkers and the potential of dexmedetomidine and sevoflurane in modulating neuroinflammation. This study provides a comprehensive overview of the evolving research landscape, highlighting the need for interdisciplinary collaboration and the development of novel therapeutic strategies to address PND. Future research should focus on elucidating the complex interactions between neuroinflammation and cognitive decline and exploring personalized interventions to improve patient outcomes.
围手术期神经认知功能障碍（PND）是老年手术患者的一种重要并发症，其特征为认知功能下降，且常与神经炎症相关。本研究利用科学引文索引核心合集（WoSCC）数据库，对1999年至2023年期间744篇关于PND相关神经炎症的出版物进行了文献计量分析。使用VOSviewer、CiteSpace和Microsoft Excel等工具分析了出版物趋势、地理分布和关键研究领域。结果显示出版物数量稳步增长，中国的产出领先，美国具有重大影响力。关键研究领域包括衰老、心脏手术、小胶质细胞活化和治疗靶点。近期研究聚焦于NLRP3炎性小体和小胶质细胞活化作为核心机制。该分析还确定了新兴趋势，如生物标志物的研究以及右美托咪定和七氟醚在调节神经炎症方面的潜力。本研究全面概述了不断演变的研究格局，强调了跨学科合作以及开发新治疗策略以解决PND的必要性。未来研究应专注于阐明神经炎症与认知功能下降之间的复杂相互作用，并探索个性化干预措施以改善患者预后。
