基底前脑胆碱能回路与认知及认知衰退中的信号传导
Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline.
作者信息
Ballinger Elizabeth C, Ananth Mala, Talmage David A, Role Lorna W
机构信息
Medical Scientist Training Program, Program in Neuroscience, Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY 11794, USA.
Program in Neuroscience, Department of Neurobiology & Behavior, Department of Psychiatry & Behavioral Science, Stony Brook University, Stony Brook, NY 11794, USA.
出版信息
Neuron. 2016 Sep 21;91(6):1199-1218. doi: 10.1016/j.neuron.2016.09.006.
Abstract
Recent work continues to place cholinergic circuits at center stage for normal executive and mnemonic functioning and provides compelling evidence that the loss of cholinergic signaling and cognitive decline are inextricably linked. This Review focuses on the last few years of studies on the mechanisms by which cholinergic signaling contributes to circuit activity related to cognition. We attempt to identify areas of controversy, as well as consensus, on what is and is not yet known about how cholinergic signaling in the CNS contributes to normal cognitive processes. In addition, we delineate the findings from recent work on the extent to which dysfunction of cholinergic circuits contributes to cognitive decline associated with neurodegenerative disorders.
摘要
近期的研究继续将胆碱能回路置于正常执行功能和记忆功能的核心位置，并提供了令人信服的证据，表明胆碱能信号的丧失与认知衰退有着千丝万缕的联系。本综述聚焦于过去几年关于胆碱能信号促进与认知相关的回路活动机制的研究。我们试图确定在中枢神经系统中胆碱能信号如何促进正常认知过程这一问题上，已知和未知的方面，找出存在争议以及达成共识的领域。此外，我们还阐述了近期研究中关于胆碱能回路功能障碍在多大程度上导致与神经退行性疾病相关的认知衰退的研究结果。
相似文献
1
Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline.基底前脑胆碱能回路与认知及认知衰退中的信号传导
Neuron. 2016 Sep 21;91(6):1199-1218. doi: 10.1016/j.neuron.2016.09.006.
2
Basal Forebrain Cholinergic System and Memory.基底前脑胆碱能系统与记忆
Curr Top Behav Neurosci. 2018;37:253-273. doi: 10.1007/7854_2016_467.
3
Basal Forebrain Cholinergic Neurons Selectively Drive Coordinated Motor Learning in Mice.基底前脑胆碱能神经元选择性地驱动小鼠协调运动学习。
J Neurosci. 2021 Dec 8;41(49):10148-10160. doi: 10.1523/JNEUROSCI.1152-21.2021. Epub 2021 Nov 8.
4
Associations between a neurophysiological marker of central cholinergic activity and cognitive functions in young and older adults.年轻和老年成年人的中枢胆碱能活动的神经生理标志物与认知功能之间的关联。
Behav Brain Funct. 2012 Jun 20;8:17. doi: 10.1186/1744-9081-8-17.
5
Basal forebrain integrity, cholinergic innervation and cognition in idiopathic Parkinson's disease.特发性帕金森病中的基底前脑完整性、胆碱能神经支配与认知
Brain. 2024 May 3;147(5):1799-1808. doi: 10.1093/brain/awad420.
6
Optogenetic Dissection of the Basal Forebrain Neuromodulatory Control of Cortical Activation, Plasticity, and Cognition.基底前脑对皮层激活、可塑性和认知的神经调节控制的光遗传学剖析
J Neurosci. 2015 Oct 14;35(41):13896-903. doi: 10.1523/JNEUROSCI.2590-15.2015.
7
Basal Forebrain Cholinergic Neurons Primarily Contribute to Inhibition of Electroencephalogram Delta Activity, Rather Than Inducing Behavioral Wakefulness in Mice.基底前脑胆碱能神经元主要对小鼠脑电图δ活动的抑制起作用，而非诱导行为觉醒。
Neuropsychopharmacology. 2016 Jul;41(8):2133-46. doi: 10.1038/npp.2016.13. Epub 2016 Jan 22.
8
Cellular birthdate predicts laminar and regional cholinergic projection topography in the forebrain.细胞出生日期可预测前脑皮质层状和区域胆碱能投射的拓扑结构。
Elife. 2020 Dec 23;9:e63249. doi: 10.7554/eLife.63249.
9
The effects of neonatal basal forebrain lesions on cognition: towards understanding the developmental role of the cholinergic basal forebrain.新生儿基底前脑损伤对认知的影响：旨在理解胆碱能基底前脑的发育作用
Int J Dev Neurosci. 1998 Nov-Dec;16(7-8):603-12. doi: 10.1016/s0736-5748(98)00072-0.
10
A cholinergic basal forebrain feeding circuit modulates appetite suppression.胆碱能基底前脑进食回路调节食欲抑制。
Nature. 2016 Oct 13;538(7624):253-256. doi: 10.1038/nature19789. Epub 2016 Oct 3.
引用本文的文献
1
A molecularly defined basalo-prefrontal-thalamic circuit regulates sensory and affective dimensions of pain.一个分子层面明确的基底前脑-前额叶-丘脑回路调节疼痛的感觉和情感维度。
bioRxiv. 2025 Aug 25:2025.08.22.671771. doi: 10.1101/2025.08.22.671771.
2
Exploring the Anti-Alzheimer's Disease Potential of C23-3 Through Genomic Insights, Metabolomic Analysis, and Molecular Docking.通过基因组学洞察、代谢组学分析和分子对接探索C23-3的抗阿尔茨海默病潜力
J Fungi (Basel). 2025 Jul 23;11(8):546. doi: 10.3390/jof11080546.
3
Regional associations between cerebrovascular disease and cholinergic white matter pathways in the Lewy body continuum.路易体连续体中脑血管疾病与胆碱能白质通路之间的区域关联。
NPJ Parkinsons Dis. 2025 Aug 21;11(1):250. doi: 10.1038/s41531-025-01118-5.
4
Colorectal cancer cells hijack a brain-gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth.结肠直肠癌细胞劫持了一条从外侧隔到肠神经元的脑-肠多突触回路，以维持肿瘤生长。
Nat Cancer. 2025 Aug 21. doi: 10.1038/s43018-025-01033-x.
5
Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update.阿尔茨海默病中靶向铁死亡的机制、生物学及作用的研究进展：最新综述
Front Aging Neurosci. 2025 Jul 21;17:1587986. doi: 10.3389/fnagi.2025.1587986. eCollection 2025.
6
Amyloid accumulation, brain atrophy, and cognitive decline in emergent Alzheimer's disease.早发性阿尔茨海默病中的淀粉样蛋白积聚、脑萎缩和认知衰退
Alzheimers Dement (Amst). 2025 Jul 29;17(3):e70155. doi: 10.1002/dad2.70155. eCollection 2025 Jul-Sep.
7
AAV9-mediated transduction of memory circuits following convection-enhanced delivery into the olfactory bulbs.在通过对流增强递送进入嗅球后，腺相关病毒9介导的记忆回路转导。
Gene Ther. 2025 Jul 26. doi: 10.1038/s41434-025-00555-4.
8
Neuroprotective Effects of Metformin Through the Modulation of Neuroinflammation and Oxidative Stress.二甲双胍通过调节神经炎症和氧化应激发挥神经保护作用。
Cells. 2025 Jul 11;14(14):1064. doi: 10.3390/cells14141064.
9
Immunohistochemical relationships of huntingtin-associated protein 1 with choline acetyltransferase in the forebrain cholinergic nuclei of adult mice.成年小鼠前脑胆碱能核团中亨廷顿蛋白相关蛋白1与胆碱乙酰转移酶的免疫组织化学关系
Cell Tissue Res. 2025 Jul 19. doi: 10.1007/s00441-025-03996-w.
10
Targeting Neuronal Alpha7 Nicotinic Acetylcholine Receptor Upregulation in Age-Related Neurological Disorders.靶向年龄相关性神经疾病中神经元α7烟碱型乙酰胆碱受体上调
Cell Mol Neurobiol. 2025 Jul 16;45(1):70. doi: 10.1007/s10571-025-01586-6.
本文引用的文献
1
Cholinergic genetics of visual attention: Human and mouse choline transporter capacity variants influence distractibility.视觉注意力的胆碱能遗传学：人类和小鼠胆碱转运体能力变异影响注意力分散。
J Physiol Paris. 2016 Sep;110(1-2):10-18. doi: 10.1016/j.jphysparis.2016.07.001. Epub 2016 Jul 9.
2
Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer's disease patients: application of a second-generation encapsulated cell biodelivery device.将神经生长因子靶向递送至阿尔茨海默病患者的胆碱能基底前脑：第二代封装细胞生物递送装置的应用
Alzheimers Res Ther. 2016 Jul 7;8(1):30. doi: 10.1186/s13195-016-0195-9.
3
The role of basal forebrain cholinergic neurons in fear and extinction memory.基底前脑胆碱能神经元在恐惧和消退记忆中的作用。
Neurobiol Learn Mem. 2016 Sep;133:39-52. doi: 10.1016/j.nlm.2016.06.001. Epub 2016 Jun 2.
4
An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior.一种表观遗传机制介导发育过程中尼古丁对神经元结构和行为的影响。
Nat Neurosci. 2016 Jul;19(7):905-14. doi: 10.1038/nn.4315. Epub 2016 May 30.
5
Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain.大脑中的异源α7β2烟碱型乙酰胆碱受体
Trends Pharmacol Sci. 2016 Jul;37(7):562-574. doi: 10.1016/j.tips.2016.03.005. Epub 2016 May 11.
6
Selectivity of Neuromodulatory Projections from the Basal Forebrain and Locus Ceruleus to Primary Sensory Cortices.从基底前脑和蓝斑到初级感觉皮层的神经调节投射的选择性
J Neurosci. 2016 May 11;36(19):5314-27. doi: 10.1523/JNEUROSCI.4333-15.2016.
7
Soluble Amyloid-β42 Stimulates Glutamate Release through Activation of the α7 Nicotinic Acetylcholine Receptor.可溶性淀粉样β蛋白42通过激活α7烟碱型乙酰胆碱受体刺激谷氨酸释放。
J Alzheimers Dis. 2016 May 3;53(1):337-47. doi: 10.3233/JAD-160041.
8
Cholinergic Signaling Controls Conditioned Fear Behaviors and Enhances Plasticity of Cortical-Amygdala Circuits.胆碱能信号传导控制条件性恐惧行为并增强皮质-杏仁核回路的可塑性。
Neuron. 2016 Jun 1;90(5):1057-70. doi: 10.1016/j.neuron.2016.04.028. Epub 2016 May 5.
9
The Basal Forebrain and Motor Cortex Provide Convergent yet Distinct Movement-Related Inputs to the Auditory Cortex.基底前脑和运动皮层向听觉皮层提供汇聚但不同的与运动相关的输入。
Neuron. 2016 May 4;90(3):635-48. doi: 10.1016/j.neuron.2016.03.031. Epub 2016 Apr 21.
10
Cholinergic modulation of auditory P3 event-related potentials as indexed by CHRNA4 and CHRNA7 genotype variation in healthy volunteers.健康志愿者中由CHRNA4和CHRNA7基因型变异所指示的听觉P3事件相关电位的胆碱能调节。
Neurosci Lett. 2016 Jun 3;623:36-41. doi: 10.1016/j.neulet.2016.04.040. Epub 2016 Apr 22.
Zotero 插件