Ballinger Elizabeth C, Ananth Mala, Talmage David A, Role Lorna W
Medical Scientist Training Program, Program in Neuroscience, Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY 11794, USA.
Program in Neuroscience, Department of Neurobiology & Behavior, Department of Psychiatry & Behavioral Science, Stony Brook University, Stony Brook, NY 11794, USA.
Neuron. 2016 Sep 21;91(6):1199-1218. doi: 10.1016/j.neuron.2016.09.006.
Recent work continues to place cholinergic circuits at center stage for normal executive and mnemonic functioning and provides compelling evidence that the loss of cholinergic signaling and cognitive decline are inextricably linked. This Review focuses on the last few years of studies on the mechanisms by which cholinergic signaling contributes to circuit activity related to cognition. We attempt to identify areas of controversy, as well as consensus, on what is and is not yet known about how cholinergic signaling in the CNS contributes to normal cognitive processes. In addition, we delineate the findings from recent work on the extent to which dysfunction of cholinergic circuits contributes to cognitive decline associated with neurodegenerative disorders.
近期的研究继续将胆碱能回路置于正常执行功能和记忆功能的核心位置，并提供了令人信服的证据，表明胆碱能信号的丧失与认知衰退有着千丝万缕的联系。本综述聚焦于过去几年关于胆碱能信号促进与认知相关的回路活动机制的研究。我们试图确定在中枢神经系统中胆碱能信号如何促进正常认知过程这一问题上，已知和未知的方面，找出存在争议以及达成共识的领域。此外，我们还阐述了近期研究中关于胆碱能回路功能障碍在多大程度上导致与神经退行性疾病相关的认知衰退的研究结果。
