Molecular targets of the Warburg effect and inflammatory cytokines in the pathogenesis of pulmonary artery hypertension.

Pulmonary arterial hypertension (PAH) is a progressive vascular disease characterized by increased pulmonary arterial pressure and vasoconstriction and structural remolding of pulmonary arterioles. Recent clinical and experimental studies have discovered the relationship between metabolic alterations and the pathogenesis of PAH. The primary metabolic alteration, previously demonstrated in various cancers, is a gradual change in energy generated from complete aerobic cellular respiration to from solely "aerobic glycolysis," termed the "Warburg effect." Understanding the Warburg effect of metabolic dysregulation and its interaction with inflammatory mechanisms in the pathogenesis of PAH has provided a valuable explanation of this disease and has guided formulation of new clinical treatments at the molecular level.