Movahedian Attar Bijan, Naghdi Navid, Etemadi Sh Milad, Mehdizadeh Mojdeh
Associated Professor, Torabinejad Dental Research Center, Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Postgraduate Student of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, Isfahan University of Medical Sciences, Isfahan, Iran.
J Oral Maxillofac Surg. 2017 May;75(5):1026-1035. doi: 10.1016/j.joms.2016.12.026. Epub 2016 Dec 26.
Secondary grafting of alveolar defects with iliac crest bone is a common treatment method in cleft patients. The aim of this study was to evaluate the effectiveness of the combination of symphysis bone, allograft, and platelet-rich fibrin in regeneration of alveolar defects compared with iliac bone graft.
In this randomized clinical trial, patients with unilateral alveolar defects were divided randomly into two categories. Group A comprised patients in whom the combination of chin symphysis bone plus allogeneic bone material plus leukocyte- and platelet-rich fibrin was considered for treatment. Group B comprised patients in whom iliac bone graft was considered. Cone beam computed tomography before treatment and 1 year postoperatively was used for measurement of bone formation (bone volume in cubic centimeters). The data were analyzed by paired t and χ tests via SPSS software (version 23; IBM, Armonk, NY). P < .05 was considered significant.
Each group included 10 patients (with 6 male patients in group A and 5 male patients in group B). The mean age of patients in groups A and B was 9.5 ± 1.5 years and 9.9 ± 1.9 years, respectively. The mean volume of alveolar defects was 0.89 ± 0.29 cm in group A and 0.95 ± 0.27 cm in group B. The percentage of bone regeneration in groups A and B was 69.5% and 73.8%, respectively.
It seems that chin symphysis bone plus allogeneic bone material plus platelet-rich fibrin is a proper combination for bone regeneration in alveolar defects with a small to moderate volume range.
采用髂嵴骨对牙槽嵴缺损进行二期植骨是腭裂患者常用的治疗方法。本研究旨在评估联合使用下颌骨联合部骨、同种异体骨和富血小板纤维蛋白与髂骨移植相比，在牙槽嵴缺损再生中的有效性。
在这项随机临床试验中，单侧牙槽嵴缺损患者被随机分为两组。A组患者采用下颌骨联合部骨加同种异体骨材料加富白细胞和血小板纤维蛋白联合治疗。B组患者采用髂骨移植治疗。治疗前及术后1年采用锥形束计算机断层扫描测量骨形成情况（以立方厘米为单位的骨体积）。通过SPSS软件（版本23；IBM，纽约州阿蒙克）进行配对t检验和χ检验分析数据。P <.05被认为具有统计学意义。
每组包括10例患者（A组6例男性患者，B组5例男性患者）。A组和B组患者的平均年龄分别为9.5±1.5岁和9.9±1.9岁。A组牙槽嵴缺损的平均体积为0.89±0.29 cm，B组为0.95±0.27 cm。A组和B组的骨再生百分比分别为69.5%和73.8%。
下颌骨联合部骨加同种异体骨材料加富血小板纤维蛋白似乎是小至中等体积范围牙槽嵴缺损骨再生的合适组合。
