Francisco Inês, Fernandes Maria Helena, Vale Francisco
Institute of Orthodontics, Faculty of Medicine of the University of Coimbra, 3000-075 Coimbra, Portugal.
Faculty of Dental Medicine, University of Porto, 4200-393 Porto, Portugal.
Materials (Basel). 2020 Apr 16;13(8):1866. doi: 10.3390/ma13081866.
Preservation of the alveolar bone is a determinant in the outcome of orthodontic treatment. Alveolar bone defects or a decrease of their height and width may occur due to common reasons such as inflammation, tooth extraction, or cleft lip and palate. The aim of this systematic review was to investigate and appraise the quality of the most up to date available evidence regarding the applications and effects of platelet-rich fibrin (PRF) in orthodontics. This study was carried out according to preferred reporting items for systematic reviews and meta-analyses guidelines using the following databases: Medline via PubMed, Cochrane Library, Web of Science Core Collection and EMBASE. The qualitative assessment of the included studies was performed using Cochrane Risk of Bias tool and ROBINS-I guidelines. Results: From a total of 489 studies, nine studies were selected. The majority of the included studies demonstrate that autogenous anterior iliac graft with PRF had a higher amount of newly formed bone. Furthermore, this review also suggests that the application of platelet derivatives in the extraction socket can accelerate orthodontic tooth movement. Despite the limitations in the included studies, this systematic review suggested that PRF can improve alveolar cleft reconstruction and orthodontic tooth movement.
牙槽骨的保存是正畸治疗结果的一个决定因素。由于炎症、拔牙或唇腭裂等常见原因，可能会出现牙槽骨缺损或其高度和宽度的减小。本系统评价的目的是调查和评估关于富血小板纤维蛋白（PRF）在正畸学中的应用和效果的最新可用证据的质量。本研究按照系统评价和Meta分析的首选报告项目指南，使用以下数据库进行：通过PubMed的Medline、Cochrane图书馆、科学网核心合集和EMBASE。使用Cochrane偏倚风险工具和ROBINS-I指南对纳入研究进行定性评估。结果：从总共489项研究中，筛选出9项研究。大多数纳入研究表明，自体髂前骨移植联合PRF能形成更多的新骨。此外，本综述还表明，在拔牙窝中应用血小板衍生物可加速正畸牙齿移动。尽管纳入研究存在局限性，但本系统评价表明，PRF可改善牙槽裂修复和正畸牙齿移动。
