Barreca Maria Magdalena, Aliotta Emanuele, Geraci Fabiana
Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF) Sez Biologia Cellulare ed.16, University of Palermo, Viale delle Scienze, Palermo, 90128, Italy.
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy.
Adv Exp Med Biol. 2017;958:1-9. doi: 10.1007/978-3-319-47861-6_1.
Extracellular vesicles are recently described as specialized structures for intercellular communication. Their role in the central nervous system was diffusely studied in both physiological and pathological condition. In particular, an increased extracellular vesicle number was detected in several autoimmune diseases, including multiple sclerosis, a chronic autoimmune, inflammatory, demyelinating and neurodegenerative disease. This chapter summarizes the available information on the involvement of the extracellular vesicles in multiple sclerosis pathogenesis and their possible use as biomarker of therapy efficacy.
细胞外囊泡最近被描述为细胞间通讯的特殊结构。它们在中枢神经系统中的作用在生理和病理条件下都得到了广泛研究。特别是，在包括多发性硬化症（一种慢性自身免疫性、炎症性、脱髓鞘和神经退行性疾病）在内的几种自身免疫性疾病中，检测到细胞外囊泡数量增加。本章总结了关于细胞外囊泡参与多发性硬化症发病机制的现有信息，以及它们作为治疗效果生物标志物的可能用途。
