Key Laboratory for Advanced Materials & Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, PR China.
National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 189 Guo Shoujing Road, Shanghai 201203, PR China.
ACS Appl Mater Interfaces. 2017 Feb 1;9(4):3272-3276. doi: 10.1021/acsami.6b14249. Epub 2017 Jan 19.
A supramolecular, polymer-dot-based ensemble has been developed for the ratiometric detection of lectins and targeted delivery of glycoprobes. Self-assembly between a blue-emitting polymer dot and a red-emitting glycoprobe, results in an ensemble that shows red emission upon excitation of the polymer dot because of Förster resonance energy transfer. Resulting in ratiometric detection of lectins in buffer solution as well as targeted delivery of the glycoprobe to cells that highly express a sugar receptor. Unlike conventional systems where both the agent and vector are codelivered intracellularly, our ensemble developed here shows a receptor-controlled dissociation on the cell membrane.
已开发出一种基于超分子聚合物点的集合体，用于比率检测凝集素和糖探针的靶向递送。蓝色发射聚合物点与红色发射糖探针之间的自组装导致聚合物点激发时的集合体显示红色发射，因为Förster 共振能量转移。导致缓冲溶液中凝集素的比率检测以及对高度表达糖受体的细胞的糖探针的靶向递送。与传统系统不同，传统系统中的试剂和载体都是在细胞内共递的，我们在此开发的集合体在细胞膜上显示出受体控制的解离。
