手性锍盐促进的 N-叔丁基亚磺酰基异羟肟酸酯的对映选择性 α-羟胺化反应。
Diastereoselective Electrophilic α-Hydroxyamination of N-tert-Butanesulfinyl Imidates.
机构信息
Key Laboratory of Plant Resources and Chemistry of Arid Zones, Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences , Urumqi 830011, China.
University of Chinese Academy of Sciences , Beijing 100049, China.
出版信息
Org Lett. 2017 Feb 3;19(3):670-673. doi: 10.1021/acs.orglett.6b03835. Epub 2017 Jan 17.
PMID:28093907
Abstract
Diastereoselective α-hydroxyamination of N-tert-butanesulfinyl imidates using nitrosoarenes is reported. A catalytic amount of base effectively promotes the hydroxyamination reaction of α-aryl-substituted imidates, and the resulting α-hydroxyamino imidates can be transformed into a range of synthetically useful intermediates.
摘要
本文报道了使用亚硝基芳烃对 N-叔丁基亚磺酰基异氰酸酯进行非对映选择性的α-羟胺化反应。催化量的碱能有效地促进α-芳基取代异氰酸酯的羟胺化反应，得到的α-羟氨基异氰酸酯可以转化为一系列合成上有用的中间体。
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