Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
Trends Immunol. 2017 Mar;38(3):168-180. doi: 10.1016/j.it.2016.12.006. Epub 2017 Jan 13.
In the immune system, the vitamin A metabolite retinoic acid (RA) is known for its role in inducing gut-homing molecules in T and B cells, inducing regulatory T cells (Tregs), and promoting tolerance. However, it was suggested that RA can have a broad spectrum of effector functions depending on the local microenvironment. Under specific conditions, RA can also promote an inflammatory environment. We discuss the dual role of RA in immune responses and how this might be regulated. Furthermore, we focus on the role of RA in autoimmune diseases and whether RA might be used as a therapeutic agent.
在免疫系统中，维生素 A 代谢产物视黄酸（RA）以诱导 T 和 B 细胞中肠道归巢分子、诱导调节性 T 细胞（Tregs）和促进耐受而闻名。然而，有人认为 RA 可以根据局部微环境发挥广泛的效应功能。在特定条件下，RA 也可以促进炎症环境。我们讨论了 RA 在免疫反应中的双重作用以及这种作用可能如何受到调节。此外，我们还关注 RA 在自身免疫性疾病中的作用以及 RA 是否可用作治疗剂。
