a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics , Xiamen University , Xiamen , Fujian , China.
b Key Laboratory of Health Technology Assessment of Fujian Province University, School of Public Health , Xiamen University , Xiamen , Fujian , China.
Aging Ment Health. 2018 Apr;22(4):519-525. doi: 10.1080/13607863.2016.1277976. Epub 2017 Jan 17.
The objective of this study was to examine whether loneliness was associated with the risk of developing dementia in Chinese older adults and whether the association was moderated by gender.
A 3-year cohort study was conducted using data from the 2008/2009 and 2011/2012 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Multiple logistic regression was used to analyze the relationship between loneliness and dementia. The interaction between loneliness and gender was also evaluated.
At 3-year follow-up, 393 of the 7867 participants had dementia. Loneliness was associated with dementia (odds ratio (OR) = 1.31, 95% confidence interval (CI) = 1.11-1.56) after adjustment for sociodemographic characteristics, lifestyle, and baseline health status. A significant interaction between loneliness and gender was also found (OR = 0.81, 95% CI = 0.65-0.99).
Loneliness increased the risk of developing dementia among people aged 65 years and older in China. Moreover, the effect of loneliness on dementia risk varied by gender. Specifically, men who felt lonely were more likely to suffer from dementia than women.
本研究旨在探讨孤独感是否与中国老年人痴呆的发病风险相关，以及这种相关性是否受性别影响。
本研究采用 2008/2009 年和 2011/2012 年中国健康长寿纵向研究（CLHLS）的数据进行了为期 3 年的队列研究。采用多因素 logistic 回归分析孤独感与痴呆的关系，并评估孤独感与性别之间的交互作用。
在 3 年的随访中，7867 名参与者中有 393 人患有痴呆症。调整社会人口特征、生活方式和基线健康状况后，孤独感与痴呆症相关（比值比（OR）=1.31，95%置信区间（CI）=1.11-1.56）。此外，还发现孤独感与性别之间存在显著的交互作用（OR=0.81，95%CI=0.65-0.99）。
孤独感增加了中国 65 岁及以上人群发生痴呆的风险。此外，孤独感对痴呆风险的影响存在性别差异，即感到孤独的男性比女性更容易患痴呆症。
