Park Eunduck, Meininger Janet C, Kang Duck-Hee, Gabriel Kelley Pettee, Padhye Nikhil S
School of Nursing, The University of Texas Health Science Center at Houston, , Houston, Texas, 77030.
School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, 77030.
Am J Hum Biol. 2017 May 6;29(3). doi: 10.1002/ajhb.22959. Epub 2017 Jan 17.
Cardiorespiratory fitness (fitness) has been inversely associated with inflammation, but whether the association is attributed to fitness itself or lower levels of adiposity remains uncertain in young adults. The purpose of this study was to determine the association of fitness and adiposity with inflammation in young adults.
A cross-sectional study was conducted with 88 participants aged 20-34 years. Fitness was assessed by a submaximal treadmill walking test. Adiposity was assessed by body mass index (BMI) and waist circumference (WC). Inflammation was measured by plasma C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) levels using immunoassays. Biological data were log transformed. A separate multiple regression analysis was conducted with each inflammatory biomarker as a dependent variable. Covariates (sex, oral contraceptive use, and education level) were adjusted.
Fitness was inversely associated with log CRP after adjustment for covariates but not after adjusting for BMI or WC. Fitness was inversely associated with log IL-6 after adjustment for WC and covariates (β = -0.341, P = .049) but not after adjusting for BMI. Fitness × WC interaction (partial eta = 0.056, P = .033) indicated that high fitness was more strongly associated with low log IL-6 in young adults with high WC than those with low WC.
Although adiposity has a stronger association than fitness with CRP and IL-6, higher levels of fitness could be essential for maintaining low levels of IL-6, especially in the presence of high levels of central adiposity.
心肺适能与炎症呈负相关，但在年轻人中，这种关联是归因于心肺适能本身还是较低的肥胖水平仍不确定。本研究的目的是确定年轻人心肺适能和肥胖与炎症之间的关联。
对88名年龄在20 - 34岁的参与者进行了一项横断面研究。通过次极量跑步机步行试验评估心肺适能。通过体重指数（BMI）和腰围（WC）评估肥胖程度。使用免疫测定法通过血浆C反应蛋白（CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平测量炎症。对生物学数据进行对数转换。以每种炎症生物标志物作为因变量进行单独的多元回归分析。对协变量（性别、口服避孕药使用情况和教育水平）进行了调整。
在调整协变量后，心肺适能与对数CRP呈负相关，但在调整BMI或WC后则不然。在调整WC和协变量后，心肺适能与对数IL-6呈负相关（β = -0.341，P = 0.049），但在调整BMI后则不然。心肺适能×WC交互作用（偏η = 0.056，P = 0.033）表明，与低WC的年轻人相比，高WC的年轻人中，高心肺适能与低对数IL-6的关联更强。
尽管肥胖与CRP和IL-6的关联比心肺适能更强，但较高水平的心肺适能对于维持低水平的IL-6可能至关重要，尤其是在存在高水平中心性肥胖的情况下。
