Haapala Eero A, Lankhorst Kristel, de Groot Janke, Zwinkels Maremka, Verschuren Olaf, Wittink Harriet, Backx Frank Jg, Visser-Meily Anne, Takken Tim
1 Faculty of Sport and Health Sciences, University of Jyväskylä, Finland.
2 Institute of Biomedicine, University of Eastern Finland, Finland.
Eur J Prev Cardiol. 2017 Jul;24(10):1102-1111. doi: 10.1177/2047487317702792. Epub 2017 Apr 4.
Background The evidence on the associations of cardiorespiratory fitness, body adiposity and sports participation with arterial stiffness in children and adolescents with chronic diseases or physical disabilities is limited. Methods Altogether 140 children and adolescents with chronic diseases or physical disabilities participated in this cross-sectional study. Cardiorespiratory fitness was assessed using maximal exercise test with respiratory gas analyses either using shuttle run, shuttle ride, or cycle ergometer test. Cardiorespiratory fitness was defined as peak oxygen uptake by body weight or fat-free mass. Body adiposity was assessed using waist circumference, body mass index standard deviation score and body fat percentage. Sports participation was assessed by a questionnaire. Aortic pulse wave velocity and augmentation index were assessed by a non-invasive oscillometric tonometry device. Results Peak oxygen uptake/body weight (standardised regression coefficient β -0.222, 95% confidence interval (CI) -0.386 to -0.059, P = 0.002) and peak oxygen uptake/fat-free mass (β -0.173, 95% CI -0.329 to -0.017, P = 0.030) were inversely and waist circumference directly (β 0.245, 95% CI 0.093 to 0.414, P = 0.002) associated with aortic pulse wave velocity. However, the associations of the measures of cardiorespiratory fitness with aortic pulse wave velocity were attenuated after further adjustment for waist circumference. A higher waist circumference (β -0.215, 95% CI -0.381 to -0.049, P = 0.012) and a higher body mass index standard deviation score (β 0.218, 95% CI -0.382 to -0.054, P = 0.010) were related to lower augmentation index. Conclusions Poor cardiorespiratory fitness and higher waist circumference were associated with increased arterial stiffness in children and adolescents with chronic diseases and physical disabilities. The association between cardiorespiratory fitness and arterial stiffness was partly explained by waist circumference.
关于患有慢性疾病或身体残疾的儿童和青少年的心肺适能、身体肥胖及运动参与与动脉僵硬度之间关联的证据有限。方法：共有140名患有慢性疾病或身体残疾的儿童和青少年参与了这项横断面研究。通过使用穿梭跑、穿梭骑行或自行车测力计测试并结合呼吸气体分析的最大运动测试来评估心肺适能。心肺适能定义为每体重或去脂体重的峰值摄氧量。使用腰围、体重指数标准差评分和体脂百分比来评估身体肥胖情况。通过问卷调查评估运动参与情况。使用无创示波测压装置评估主动脉脉搏波速度和增强指数。结果：峰值摄氧量/体重（标准化回归系数β -0.222，95%置信区间（CI）-0.386至-0.059，P = 0.002）和峰值摄氧量/去脂体重（β -0.173，95% CI -0.329至-0.017，P = 0.030）与主动脉脉搏波速度呈负相关，而腰围与之呈正相关（β 0.245，95% CI 0.093至0.414，P = 0.002）。然而，在进一步调整腰围后，心肺适能指标与主动脉脉搏波速度之间的关联减弱。较高的腰围（β -0.215，95% CI -0.381至-0.049，P = 0.012）和较高的体重指数标准差评分（β 0.218，95% CI -0.382至-0.054，P = 0.010）与较低的增强指数相关。结论：患有慢性疾病和身体残疾的儿童和青少年心肺适能差和腰围较高与动脉僵硬度增加有关。心肺适能与动脉僵硬度之间的关联部分可由腰围来解释。
