Alexis Neil E, Bennett William, Peden David Blaine
a Department of Pediatrics, Division of Allergy, Immunology and Rheumatology, Center for Environmental Medicine , Asthma and Lung Biology, University of North Carolina Chapel Hill , Chapel Hill , NC , USA.
b Center for Environmental Medicine , Asthma and Lung Biology, Division of Allergy and Immunology, University of North Carolina School of Medicine , Chapel Hill , NC , USA.
J Asthma. 2017 Nov;54(9):957-960. doi: 10.1080/02770903.2016.1278019. Epub 2017 Jan 17.
To determine whether induced sputum (IS) with hypertonic saline inhalation is safe to use in asthmatics within 24 hours of two commonly used airway challenges, namely endotoxin and dust mite allergen, and to assess whether IS can enhance mucociliary clearance (MCC) rates in asthmatics.
IS (three 7-minute inhalation periods of 3%, 4%, and 5% hypertonic saline) was employed before (N = 29) and within 24 hours of inhaled challenges with endotoxin (N = 13) and dust mite allergen (N = 12) in a cohort of mild to moderate asthmatics. Safety was assessed by lung function (Forced Expiratory Volume in 1 second; FEV1) and MCC was measured using a radiolabeled gamma scintigraphy method (Tcm99 sulfur colloid). IS was performed pre and post MCC.
No significant lung function decrement was observed before or after inhaled challenges with endotoxin or dust mite allergen. IS significantly enhanced MCC rates before and after inhaled endotoxin challenge.
Based on a small cohort, IS is safe to use in mild to moderate asthmatics before and within 24 hours of inhaled challenges with endotoxin and dust mite allergen. Furthermore, IS has beneficial effects on host defense function in asthmatics by enhancing MCC rates.
确定在两种常用气道激发试验（即内毒素和尘螨过敏原）后24小时内，对哮喘患者使用高渗盐水诱导痰（IS）是否安全，并评估IS是否能提高哮喘患者的黏液纤毛清除率（MCC）。
在一组轻度至中度哮喘患者中，在吸入内毒素（N = 13）和尘螨过敏原（N = 12）之前（N = 29）以及吸入激发试验后24小时内采用IS（3%、4%和5%高渗盐水各进行三个7分钟的吸入期）。通过肺功能（一秒用力呼气容积；FEV1）评估安全性，并使用放射性标记的γ闪烁扫描法（锝99硫胶体）测量MCC。在MCC前后进行IS。
在内毒素或尘螨过敏原吸入激发试验前后，未观察到显著的肺功能下降。IS在吸入内毒素激发试验前后均显著提高了MCC率。
基于一个小队列研究，在轻度至中度哮喘患者吸入内毒素和尘螨过敏原之前及之后24小时内使用IS是安全的。此外，IS通过提高MCC率对哮喘患者的宿主防御功能具有有益作用。
