Hamel Rodolphe, Ferraris Pauline, Wichit Sineewanlaya, Diop Fodé, Talignani Loïc, Pompon Julien, Garcia Déborah, Liégeois Florian, Sall Amadou A, Yssel Hans, Missé Dorothée
Laboratoire MIVEGEC, UMR 224 IRD/CNRS/UM, Montpellier, France.
Institut Pasteur, Dakar, Senegal.
Infect Genet Evol. 2017 Apr;49:134-137. doi: 10.1016/j.meegid.2017.01.015. Epub 2017 Jan 14.
ZIKA virus (ZIKV) is a newly emerging arbovirus. Since its discovery 60years ago in Uganda, it has spread throughout the Pacific, Latin America and the Caribbean, emphasizing the capacity of ZIKV to spread to non-endemic regions worldwide. Although infection with ZIKV often leads to mild disease, its recent emergence in the Americas has coincided with an increase in adults developing Guillain-Barré syndrome and neurological complications in new-borns, such as congenital microcephaly. Many questions remain unanswered regarding the complications caused by different primary isolates of ZIKV. Here, we report the permissiveness of primary human astrocytes for two clinically relevant, Asian and African ZIKV strains and show that both isolates strongly induce antiviral immune responses in these cells albeit with markedly different kinetics. This study describes for the first time the specific antiviral gene expression in infected primary human astrocytes, the major glial cells within the central nervous system.
寨卡病毒（ZIKV）是一种新出现的虫媒病毒。自60年前在乌干达被发现以来，它已传播至整个太平洋地区、拉丁美洲和加勒比地区，凸显了寨卡病毒传播到全球非流行地区的能力。虽然感染寨卡病毒通常会导致轻症疾病，但它最近在美洲出现的同时，成人患格林-巴利综合征以及新生儿出现神经并发症（如先天性小头畸形）的情况有所增加。关于不同寨卡病毒原始分离株所引起的并发症，仍有许多问题未得到解答。在此，我们报告了原代人星形胶质细胞对两种具有临床相关性的亚洲和非洲寨卡病毒株的易感性，并表明这两种分离株均能在这些细胞中强烈诱导抗病毒免疫反应，尽管其动力学有显著差异。这项研究首次描述了受感染的原代人星形胶质细胞（中枢神经系统内主要的神经胶质细胞）中的特异性抗病毒基因表达。
